• Source: Sodium-dependent neutral amino acid transporter B(0)AT2

Sodium-dependent neutral amino acid transporter B(0)AT2 is a protein that in humans is encoded by the SLC6A15 gene.




Function


SLC6A15 shows structural characteristics of an Na+ and Cl−-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.




Clinical relevance


Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.




References






Further reading

Kata Kunci Pencarian:

• Sodium-dependent neutral amino acid transporter B(0)AT2
• GABA transporter type 1