• Source: SPINK1

Pancreatic secretory trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein that in humans is encoded by the SPINK1 gene.
Mutations in SPINK1 has been associated with hereditary pancreatitis and tropical pancreatitis. Trypsinogen is normally created and stored an inactive zymogen of trypsin in the pancreas, but occasionally will autoactivate itself. PSTI serves to cleave prematurely activated trypsin to prevent the enzyme from causing cellular damage to the organ. Without the function of PSTI, the pancreas is subject to repeated episodes of damage.
It has also been associated with prostate cancer.




See also


Kazal-type serine protease inhibitor domain
Pancreatitis




References






Further reading

Kata Kunci Pencarian:

• SPINK1
• Cassava
• Chronic pancreatitis
• Trypsinogen
• Trypsin
• Pancreatitis (veterinary)
• Pancreatitis
• Cystic fibrosis transmembrane conductance regulator
• Germinoma
• List of human protein-coding genes 4