- Source: SRA1
Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein that in humans is encoded by the SRA1 gene. The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1. This functional RNA also encodes a protein.
Function
This gene is involved in transcriptional coactivation by steroid receptor. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.
Interactions
SRA1 has been shown to interact with:
Estrogen receptor alpha,
DDX17,
Nuclear receptor coactivator 2, and
SPEN.
The SRAP has been shown to interact with its SRA RNA counterpart indirectly with the functional sub-structure STR7 of SRA RNA. Originally proposed to be RRM containing, SRAP has been demonstrated to have a helix bundle at its C-terminal end while N-terminal to this domain appears unstructured.
References
Further reading
External links
SRA1 human gene location in the UCSC Genome Browser.
SRA1 human gene details in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q9HD15 (Human Steroid receptor RNA activator 1) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: Q80VJ2 (Mouse Steroid receptor RNA activator 1) at the PDBe-KB.
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