• Source: SUZ12

Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene.




Function


This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined.
SUZ12, as part of Polycomb Repressive Complex 2 (PRC2), may be involved with chromatin silencing in conjunction with HOTAIR ncRNA, using its zinc-finger domain to bind the RNA molecule.




References






Further reading






External links


FactorBook SUZ12

Kata Kunci Pencarian:

• SUZ12
• PRC2
• Neurofibromatosis type I
• XIST
• EZH2
• DNA microarray
• Suz12 polycomb repressive complex 2 subunit pseudogene 1
• Polycomb-group proteins
• AEBP2
• Long non-coding RNA