- Source: Thymidine-triphosphatase
In enzymology, a thymidine-triphosphatase (EC 3.6.1.39) is an enzyme that catalyzes the chemical reaction
dTTP + H2O
⇌
{\displaystyle \rightleftharpoons }
dTDP + phosphate
Thus, the two substrates of this enzyme are dTTP and H2O, whereas its two products are dTDP and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dTTP nucleotidohydrolase. Other names in common use include thymidine triphosphate nucleotidohydrolase, dTTPase, and deoxythymidine-5'-triphosphatase. This enzyme participates in pyrimidine metabolism.
References
Dahlmann N (December 1982). "Human serum thymidine triphosphate nucleotidohydrolase: purification and properties of a new enzyme". Biochemistry. 21 (26): 6634–9. doi:10.1021/bi00269a004. PMID 6297538.
Kata Kunci Pencarian:
- Thymidine-triphosphatase
- List of EC numbers (EC 3)
- DNA oxidation
- DNA damage theory of aging
- List of MeSH codes (D08)
