• Source: TIE1

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.




Function


TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells and platelets. TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.




See also


Angiopoietin § Tie pathway




References






External links


Receptor,+TIE-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Kata Kunci Pencarian:

• TIE1
• Immunoglobulin domain
• Northern Wu phonology
• List of human protein-coding genes 4
• Tyrosine kinase
• Chromosome 1
• Fibronectin type III domain
• Protein kinase domain
• Angiopoietin receptor
• Proteases in angiogenesis