• Source: Tight junction protein ZO-1

Tight junction protein ZO-1 also known as Zonula Occludens-1 (ZO-1), is a 220-kD peripheral membrane protein that is encoded by the TJP1 gene in humans. It belongs to the family of zonula occludens proteins (ZO-1, ZO-2, and ZO-3), which are tight junction-associated proteins and of which, ZO-1 is the first to be cloned. It was first isolated in 1986 by Stevenson and Goodenough using a monoclonal antibody raised in rodent liver to recognise a 225-kD polypeptide in whole liver homogenates and in tight junction-enriched membrane fractions. It has a role as a scaffold protein which cross-links and anchors Tight Junction (TJ) strand proteins, which are fibril-like structures within the lipid bilayer, to the actin cytoskeleton.




Function


This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell–cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene.




Interactions


Tight junction protein 1 has been shown to interact with:




See also


Tight junction




References






Further reading






External links


Overview of all the structural information available in the PDB for UniProt: Q07157 (Human Tight junction protein ZO-1) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: P39447 (Mouse Tight junction protein ZO-1) at the PDBe-KB.

Kata Kunci Pencarian:

• Sambungan ketat
• Tight junction protein ZO-1
• Tight junction protein ZO-2
• Tight junction proteins
• Tight junction
• Gap junction
• Tight junction protein
• Edema
• Occludin
• Junctional adhesion molecule
• Cingulin-like protein 1