• Source: TRADD

Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.
TRADD is an adaptor protein.




Function


The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-κB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.




Interactions


TRADD has been shown to interact with:




See also


TRAF
RIP




References






Further reading






External links


TRADD+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Kata Kunci Pencarian:

• Eric Schneiderman
• Dane DeHaan
• TRADD
• Tradd Moore
• The Lords of Discipline (film)
• The Strange Talent of Luther Strode
• The Lords of Discipline
• Jock Tradd
• Karen White
• Tumor necrosis factor
• Ghost Rider (Robbie Reyes)
• Eric Schneiderman