• Source: Transportin-3

3/info/transportin" target="_blank">Transportin-3 is a protein that in humans is encoded by the TNPO3 gene.




Function


TNPO3 is a nuclear import receptor for serine/arginine-rich (SR) proteins, including Serine/arginine-rich splicing factor 1, which are essential precursor-mRNA splicing factors.




Clinical significance


The TNPO3-IRF5 locus is implicated in primary biliary cirrhosis and systemic sclerosis.




References






Further reading

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