• Source: Trevor K. Archer

      • Trevor K. Archer is a Bahamian research scientist who is a National Institutes of Health Distinguished Investigator and deputy director at the National Institute of Environmental Health Sciences. He leads the Chromatin and Gene Expression Group, who investigate chromatin, epigenetics and embryonic stem cells pluripotency.


      Early life and education


      Archer was born in The Bahamas. He studied biochemistry at Queen's University at Kingston, and remained there for his doctorate. His doctoral research considered human and non-human primate apolipoprotein biosynthesis. He moved to the National Cancer Institute as a postdoctoral researcher working on chromatin and epigenetics, with a focus on steroid hormone activated transcription.


      Research and career


      Archer returned to Canada in 1992, where he was made an Assistant Professor and National Cancer Institute Canada scientist at University of Western Ontario. He received tenure in 1996. In 1999, he was recruited to the National Institute of Environmental Health Sciences. He was promoted to Chief of Molecular Carcinogenesis in 2003, and Chief of Epigenetics and Stem Cell Biology in 2014. He was named as an National Institutes of Health Distinguished Investigator in 2019.
      Archer's research uses genomics to study the environmental factors that impact the architecture of chromatin, and how changes to the architecture of chromatin impact gene expression, which affects health and disease. Archer showed that steroid hormone signalling can be used to understand how gene expression is controlled.
      In an interview with Molecular Cell, Archer said that throughout his career he was underestimated because of his skin color. As a Deputy Director of the National Institute of Environmental Health Sciences, Archer chaired a committee on workplace culture, where he looked to diversify the talent pool, and make the NIEHS more inclusive.


      Selected publications


      Deborah A Greer Card; Pratibha B Hebbar; Leping Li; Kevin W Trotter; Yoshihiro Komatsu; Yuji Mishina; Trevor K Archer (October 2008). "Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells". Molecular and Cellular Biology. 28 (20): 6426–38. doi:10.1128/MCB.00359-08. ISSN 0270-7306. PMC 2577422. PMID 18710938. Wikidata Q24323720.
      Fryer CJ; Trevor K Archer (1 May 1998). "Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex". Nature. 393 (6680): 88–91. Bibcode:1998Natur.393...88F. doi:10.1038/30032. ISSN 1476-4687. PMID 9590696. Wikidata Q28271105.
      T K Archer; P Lefebvre; R G Wolford; G L Hager (1 March 1992). "Transcription factor loading on the MMTV promoter: a bimodal mechanism for promoter activation". Science. 255 (5051): 1573–1576. Bibcode:1992Sci...255.1573A. doi:10.1126/SCIENCE.1347958. ISSN 0036-8075. PMID 1347958. Wikidata Q67514906.


      References

    Kata Kunci Pencarian: