- Source: Tris(2,4,6-trimethoxyphenyl)phosphine
Tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP) is a large triaryl organophosphine whose strong Lewis-basic properties make it useful as an organocatalyst for several types of chemical reactions.
Reactions
TTMPP removes the trimethylsilyl group from ketene silyl acetals (the enol ether of esters) to give enolates that can then act as strong nucleophiles. It thus serves as a catalyst for Mukaiyama aldol reactions and group-transfer chain-growth polymerization reactions.
As a Brønsted base, TTMPP can deprotonate various alcohols, giving nucleophilic alkoxides that can undergo Michael addition reactions.
TTMPP can act as a Michael nucleophile itself to catalyze Baylis–Hillman reactions.
Uses
TTMPP is used as a ligand to form palladium-phosphine catalysts which are more reactive than triphenylphosphine-based catalysts.
References
Kata Kunci Pencarian:
6.402
No More Posts Available.
No more pages to load.
