- Source: Tryptophan dimethylallyltransferase
In enzymology, a tryptophan dimethylallyltransferase (EC 2.5.1.34) is an enzyme that catalyzes the chemical reaction
dimethylallyl diphosphate + L-tryptophan
⇌
{\displaystyle \rightleftharpoons }
diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
Thus, the two substrates of this enzyme are dimethylallyl diphosphate and L-tryptophan, whereas its two products are diphosphate and 4-(3-methylbut-2-enyl)-L-tryptophan.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase. Other names in common use include dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase, dimethylallyltryptophan synthetase, dimethylallylpyrophosphate:tryptophan dimethylallyl transferase, DMAT synthetase, and 4-(gamma,gamma-dimethylallyl)tryptophan synthase.
References
Lee SL, Floss HG, Heinstein P (1976). "Purification and properties of dimethylallylpyrophosphate:tryptopharm dimethylallyl transferase, the first enzyme of ergot alkaloid biosynthesis in Claviceps. sp. SD 58". Arch. Biochem. Biophys. 177 (1): 84–94. doi:10.1016/0003-9861(76)90418-5. PMID 999297.
Kata Kunci Pencarian:
- Tryptophan dimethylallyltransferase
- Ergotamine
- 7-Dimethylallyltryptophan synthase
- List of EC numbers (EC 2)
- Cyclopiazonic acid