• Source: Uridine diphosphate galactose

Uridine diphosphate galactose (UDP-galactose) is an intermediate in the production of polysaccharides. It is important in nucleotide sugars metabolism, and is the substrate for the transferase B4GALT5.




Sugar metabolism


UDP-Galactose is especially relevant in glycolysis. It is derived from galactose an epimer of glucose, and via the Leloir pathway, it is used be used as a precursor for the metabolism of glucose into pyruvate. When lactose is hydrolyzed, D-Galactose enters the liver via the bloodstream. There, galactokinase phosphorylates it to galactose-1-phosphate using ATP. This compound then engages in a "ping-pong" reaction with UDP-Glucose, catalyzed by uridylyltransferase, yielding glucose-1-phosphate and UDP-Galactose. This glucose-1-phosphate feeds into glycolysis, while UDP-Galactose undergoes epimerization to regenerate UDP-Glucose.




See also


Galactose
UDP galactose epimerase
Uridine diphosphate




References

Kata Kunci Pencarian:

• Uridine diphosphate galactose
• Uridine
• Uridine diphosphate glucose
• Uridine diphosphate
• Uridine triphosphate
• Galactose-1-phosphate uridylyltransferase deficiency
• Uridine diphosphate N-acetylglucosamine
• UDP-glucose 4-epimerase
• Galactose 1-phosphate
• Galactose epimerase deficiency