• Source: USP14

Ubiquitin-specific protease 14 is an enzyme that in humans is encoded by the USP14 gene.
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.




Interactions


USP14 has been shown to interact with CXCR4.




References






Further reading






External links


Overview of all the structural information available in the PDB for UniProt: P54578 (Ubiquitin carboxyl-terminal hydrolase 14) at the PDBe-KB.

Kata Kunci Pencarian:

• Proteasom
• USP14
• Proteasome
• CXCR4
• Ubiquitin B
• Deubiquitinating enzyme
• Ubiquitin C
• Housekeeping gene
• List of human protein-coding genes 4
• TRIM14
• Ubiquitin A-52 residue ribosomal protein fusion product 1