- Source: YY1
YY1 (Yin Yang 1) is a transcriptional repressor protein in humans that is encoded by the YY1 gene.
Function
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "yin-yang." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. YY1 promotes enhancer-promoter chromatin loops by forming dimers and promoting DNA interactions. Its dysregulation disrupts enhancer-promoter loops and gene expression.
Clinical significance
YY1 heterozygous deletions, missense, and nonsense mutations cause Gabriele-DeVries syndrome (GADEVS), an autosomal dominant neurodevelopmental disorder characterized by intellectual disability, dysmorphic facial features, feeding problems, intrauterine growth restriction, variable cognitive impairment, behavioral problems and other congenital malformations. A website is available in order to collect and share clinical information between clinicians and the families of affected individuals.
Interactions
YY1 has been shown to interact with:
References
Further reading
External links
FactorBook YY1
Overview of all the structural information available in the PDB for UniProt: P25490 (Transcriptional repressor protein YY1) at the PDBe-KB.
Kata Kunci Pencarian:
- 2005 YY1
- 2012 VQ6
- (495930) 2006 AR2
- (250620) 2005 GE59
- (419922) 2011 BJ24
- (475016) 2005 UO
- (494658) 2000 UG11
- 2008 GV20
- (370061) 2000 YO29
- 2001 CA21
- YY1
- Promoter (genetics)
- Yin yang (disambiguation)
- List of minor planets: 3001–4000
- Transcription (biology)
- Regulatory sequence
- Meanings of minor-planet names: 3001–4000
- List of minor planets: 28001–29000
- Enhancer (genetics)
- Poly (ADP-ribose) polymerase
