Artikel: 1-phosphatidylinositol-5-phosphate 4-kinase GudangMovies21 Rebahinxxi

  • Source: 1-phosphatidylinositol-5-phosphate 4-kinase

    • In enzymology, a 5.180.24.3/?s=1" target="_blank">1-5.180.24.3/?s=phosphatidylinositol" target="_blank">phosphatidylinositol-5-phosphate 4-kinase (EC 2.7.5.180.24.3/?s=1" target="_blank">1.149) is an enzyme that catalyzes the chemical reaction

    ATP + 5.180.24.3/?s=1" target="_blank">1-phosphatidyl-1D-myo-inositol 5-phosphate



    ⇌


    {\displaystyle \rightleftharpoons }

    ADP + 5.180.24.3/?s=1" target="_blank">1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
    Thus, the two substrates of this enzyme are ATP and 5.180.24.3/?s=1" target="_blank">1-phosphatidyl-1D-myo-inositol 5-phosphate, whereas its two products are ADP and 5.180.24.3/?s=1" target="_blank">1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
    This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:5.180.24.3/?s=1" target="_blank">1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase. This enzyme is also called type II PIP kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, 5.180.24.3/?s=phosphatidylinositol" target="_blank">phosphatidylinositol signaling system, and regulation of actin cytoskeleton.


    References



    Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997). "A new pathway for synthesis of 5.180.24.3/?s=phosphatidylinositol" target="_blank">phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192–6. doi:10.1038/36621. PMID 9367159.

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1 phosphatidylinositol 4 phosphate 5 kinase