3,3,5-Trimethylcyclohexyl 3-pyridyl methylphosphonate GudangMovies21 Rebahinxxi LK21

    VP (3/?s=5" target="_blank">5.180.24.3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3/?s=3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3" target="_blank">3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3,3/?s=5" target="_blank">5.180.24.3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3/?s=3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3" target="_blank">3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3,3/?s=5" target="_blank">5-3/?s=trimethylcyclohexyl" target="_blank">Trimethylcyclohexyl 3/?s=5" target="_blank">5.180.24.3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3/?s=3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3" target="_blank">3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3-pyridyl methylphosphonate), also known as EA-1511, is an extremely toxic organophosphate nerve agent of the V-series.
    Agent VP belongs to a class of organophosphates known as 3/?s=5" target="_blank">5.180.24.3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3/?s=3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3" target="_blank">3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3-pyridyl phosphonates. These agents are extremely potent acetylcholinesterase inhibitors.


    Synthesis


    Methylphosphonic dichloride and triethylamine are dissolved in benzene. 3/?s=5" target="_blank">5.180.24.3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3/?s=3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3" target="_blank">3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3,3/?s=5" target="_blank">5.180.24.3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3/?s=3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3" target="_blank">3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3,3/?s=5" target="_blank">5-Trimethylcyclohexanol is then slowly added while stirring and cooling. The reaction temperature is maintained at 10-15 °C. The mixture is then heated to 40 °C for 1 hour. A benzene solution of 3/?s=5" target="_blank">5.180.24.3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3/?s=3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3" target="_blank">3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3,3/?s=5" target="_blank">5.180.24.3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3/?s=3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3" target="_blank">3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3,3/?s=5" target="_blank">5-3/?s=trimethylcyclohexyl" target="_blank">trimethylcyclohexyl methylphosphonochloridate is formed.
    Triethylamine is then added to reaction mixture and 3/?s=5" target="_blank">5.180.24.3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3/?s=3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3" target="_blank">3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3-pyridol is added slowly while stirring and cooling. The reaction temperature is maintained at 35 °C. The mixture is then stirred for 1 hour at room temperature. The mixture is washed with a sodium hydroxide solution and water. The solvent is then removed by distillation at reduced pressure to yield the final product. The resulting product can be converted to a quaternary salt by reacting with a haloalkane, such as methyl iodide, to produce a water-soluble agent.


    See also


    2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate
    A-234 (nerve agent)
    GV (nerve agent)
    Ro 3/?s=5" target="_blank">5.180.24.3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3/?s=3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3" target="_blank">3/?s=5" target="_blank">5.180.24.3/?s=3" target="_blank">3-0422
    V-sub x


    References

Kata Kunci Pencarian:

3,5,5-Triethyl-3-methylcyclohexene-1,4-diamine | C13H26N2 | CID ...

3,5,5-Triethyl-3-methylcyclohexene-1,4-diamine | C13H26N2 | CID ...

Solved H3C . "CH₃ H₃C a) 3,3,5-Trimethylcyclohexane b) | Chegg.com

Solved H3C . "CH₃ H₃C a) 3,3,5-Trimethylcyclohexane b) | Chegg.com

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1,1,3-Trimethyl-3-(3,5-dihydroxy-3-methyl-pentyl)-cyclohexanol-(2 ...

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1,1,3-Trimethyl-3-(3,5-dihydroxy-3-methyl-pentyl)-cyclohexanol-(2 ...

1,1,3-Trimethyl-3-(3,5-dihydroxy-3-methyl-pentyl)-cyclohexanol-(2 ...

Solved Name of the structure 3,3,5-trimethylheptane | Chegg.com

Solved Name of the structure 3,3,5-trimethylheptane | Chegg.com

Solved A) 3,3,5-Trimethylcyclohexane B) | Chegg.com

Solved A) 3,3,5-Trimethylcyclohexane B) | Chegg.com

3,5,5-Trimethylcyclohex-3-en-1-yl acetate | C11H18O2 | CID 90791 - PubChem

3,5,5-Trimethylcyclohex-3-en-1-yl acetate | C11H18O2 | CID 90791 - PubChem

1-(3,3,5-trimethyl-1-cyclohexen-1-yl)-4-[3-[1-(3,5,5-trimethyl-1 ...

1-(3,3,5-trimethyl-1-cyclohexen-1-yl)-4-[3-[1-(3,5,5-trimethyl-1 ...

3 3 5 Trimethyl Cyclohexanol Density: 0.878 At 20 C at Best Price in ...

3 3 5 Trimethyl Cyclohexanol Density: 0.878 At 20 C at Best Price in ...

Buy 3,5,5-trimethylcyclohex-3-en-1-one Industrial Grade from Shaanxi ...

Buy 3,5,5-trimethylcyclohex-3-en-1-one Industrial Grade from Shaanxi ...

TRANS-3,3,5-TRIMETHYLCYCLOHEXANOL 767-54-4 wiki

TRANS-3,3,5-TRIMETHYLCYCLOHEXANOL 767-54-4 wiki