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Anserine (β-alanyl-3-methylhistidine) is a dipeptide containing β-alanine and 3-methylhistidine. Anserine is a derivative of carnosine, which has been methylated.
Both anserine and carnosine chelate copper. Due to its methylation, anserine is more stable in serum and resistant to degradation than carnosine. Anserine can be found in the skeletal muscle and brain of mammals and birds.
The pKa of the imidazole ring of histidine, when contained in anserine, is 7.04.




Neuroprotective effects


An animal model study of Alzheimer's disease using mice found that treatment with anserine reduced memory loss. Anserine reduced glial inflammatory activity (particularly of astrocyte). The study also found that anserine-treated mice had greater pericyte surface area. The greater area of pericytes was commensurate with improved memory (pericytes wrap around brain capillary to control blood flow and gate cells from neurotoxin, blocking inflammation). The anserine-treated mice overall performed better on a spatial memory test (Morris Water Maze).
A human study on 84 elderly subjects showed that subjects who took anserine and carnosine supplements for one year showed increased blood flow in the prefrontal cortex on MRI.
A study demonstrated that the free N-terminal of histidine on anserine and carnosine protect against zinc-caused neurotoxicity and regulate the Arc pathway in which Arc protein is used to produce dendrite protein for connecting nerve cells.
Both Anserine and Carnosine are chelating agents for copper and other transition metals. Chelation of transition metals is one method used by antioxidants to protect their targets from oxidative stress as it prevents them from undergoing Fenton reactions with peroxides. In the olfactory bulbs, the concentration of both of these molecules was found to be in the millimolar range, whereas the concentration of copper was approximately 50μM. these found concentrations indicate the chelation of copper by Anserine and Carnosine.




See also



Carnosine




References

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Anserine | CAS NO.:584-85-0 | GlpBio

Anserine - definition of anserine by The Free Dictionary

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L-Anserine - Zhonglan Industry

L-Anserine - Zhonglan Industry

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Anserine hydrochloride | C10H17ClN4O3 | CID 69650560 - PubChem

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Anserine Manufacturers, Suppliers, Factory - Wholesale Price - Pioneer ...

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anserine

Daftar Isi

• Anserine - Wikipedia
• Anserine Definition & Meaning - Merriam-Webster
• Anserine | C10H16N4O3 | CID 112072 - PubChem
• Anserine is expressed in human cardiac and skeletal muscles
• What is Anserine? High and low values | Lab results explained
• Anserine - definition of anserine by The Free Dictionary
• Anserine is expressed in human cardiac and skeletal muscles
• anserine, adj. meanings, etymology and more - Oxford English …
• Anserine | definition of anserine by Medical ... - Medical Dictionary
• l -Anserine Increases Muscle Differentiation and Muscle …

Anserine - Wikipedia

Anserine (β-alanyl-3-methylhistidine) is a dipeptide containing β-alanine and 3-methylhistidine. [1] Anserine is a derivative of carnosine, which has been methylated. [2] Both anserine and carnosine chelate copper. [3] Due to its methylation, anserine is more stable in serum and resistant to degradation than carnosine. [4]

Anserine Definition & Meaning - Merriam-Webster

The meaning of ANSERINE is of, relating to, or resembling a goose. How to use anserine in a sentence.

Anserine | C10H16N4O3 | CID 112072 - PubChem

Anserine is a dipeptide comprising of beta-alanine and 3-methyl-L-histidine units. It has a role as an animal metabolite and a mouse metabolite. It is a beta-alanine derivative and a dipeptide. It is a tautomer of an anserine zwitterion.

Anserine is expressed in human cardiac and skeletal muscles

We evaluated whether anserine, a methylated analog of the dipeptide carnosine, is present in the cardiac and skeletal muscles of humans and whether the CARNMT1 gene, which encodes the anserine synthesizing enzyme carnosine‐N‐methyltransferase, is expressed in …

What is Anserine? High and low values | Lab results explained

Jan 20, 2019 · Anserine, a dietary dipeptide, is higher than the reference range. This peptide comes from fish, fowl and some animal protein, principally from tuna, salmon, chicken, turkey, duck and rabbit. Anserine does not occur in human organs but dietary uptake is …

Anserine - definition of anserine by The Free Dictionary

Define anserine. anserine synonyms, anserine pronunciation, anserine translation, English dictionary definition of anserine. adj. 1. Of or belonging to the subfamily Anserinae, which comprises the geese. 2. Of or resembling a goose; gooselike. American Heritage® Dictionary of the...

Anserine is expressed in human cardiac and skeletal muscles

We evaluated whether anserine, a methylated analog of the dipeptide carnosine, is present in the cardiac and skeletal muscles of humans and whether the CARNMT1 gene, which encodes the anserine synthesizing enzyme carnosine-N-methyltransferase, …

anserine, adj. meanings, etymology and more - Oxford English …

There are two meanings listed in OED's entry for the adjective anserine. See ‘Meaning & use’ for definitions, usage, and quotation evidence.

Anserine | definition of anserine by Medical ... - Medical Dictionary

Resembling or characteristic of a goose. 2. present in muscle and the brain. Synonym (s): N-methylcarnosine. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, or visit the webmaster's page for free fun content. Looking for online definition of anserine in the Medical Dictionary? anserine explanation free.

l -Anserine Increases Muscle Differentiation and Muscle …

May 31, 2023 · l-Anserine, an imidazole peptide, has a variety of physiological activities, but its effects on skeletal muscle differentiation and muscle contractile force remain unknown. Thus, in this study, we ...