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Anterior horn cell disease is a rare condition that affects the nerve cells in the spinal cord responsible for controlling muscle movement. These cells play a crucial role in transmitting signals from the brain to the muscles.
The most common anterior horn cell disease worldwide is poliomyelitis but effective vaccination programmes have made this condition rare in the UK, where motor neurone disease is more common. Table 1 .
One type of Motor neuron disease (MND) is known as anterior horn cell (AHC) disease. Learn more about the causes and symptoms of this condition.
Oct 11, 2020 · Motor neuron disease (MND) is said to be a progressive neurological disorder that presents with both lower motor neurons (anterior horn cells that project from the brainstem and the spinal cord to the muscle) and upper motor neuron signs (neurons that project to the brainstem and spinal cord from higher cortical centers).[1]
Jan 3, 2023 · Progressive bulbar palsy (PBP) is a form of motor neuron disease (MND). When people develop the condition, the neurons that communicate between the brain stem, spinal cord, and brain become damaged, causing symptoms like loss of speech and muscle twitching. PBP is considered a phenotype of amyotrophic lateral sclerosis (ALS).
The clinical hallmarks of anterior horn cell disease are the lower motor neuron signs of weakness, wasting (atrophy), and fasciculations. These signs may be seen alone or in combination with upper motor neuron signs (hyper-reflexia, upgoing toes) in the case of ALS.
The anterior horn cell is a motor neuron that projects from the anterior portion of the grey matter in the spinal cord to the skeletal muscle. The degeneration of these cells causes denervation of the muscles and weakness, the hallmark feature of this disease.
Amyotrophic lateral sclerosis is an insidiously developing, adult-onset, progressive anterior horn cell degeneration with associated degeneration of descending motor pathways. It has been recognized as an important clinical syndrome since the middle of the 19th century.
Anterior horn disease is one of a number of medical disorders affecting the anterior horn of the spinal cord. [1] [2] Anterior horn diseases include spinal muscular atrophy, poliomyelitis and amyotrophic lateral sclerosis.
Anterior horn cell (also known as motor neuron) diseases affect the most proximal portion of the motor unit and are primarily inherited or infectious. The spinal muscular atrophies are the major inherited disorders of the anterior horn cell.
