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      The human ARG1 gene encodes the protein arginase.


      Function


      Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.


      References




      External links


      Human ARG1 genome location and ARG1 gene details page in the UCSC Genome Browser.


      Further reading



      This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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    ARG1 (gene) - Wikipedia

    ARG1 (gene) - Wikipedia

    ARG1 (gene) - Wikipedia

    ARG1 (gene) - Wikipedia

    ARG1 Gene - GeneCards | ARGI1 Protein | ARGI1 Antibody

    ARG1 Gene - GeneCards | ARGI1 Protein | ARGI1 Antibody

    One Gene, One Enzyme

    One Gene, One Enzyme

    ARG1 gene test results: A is NCBI reference sequence; B is gene ...

    ARG1 gene test results: A is NCBI reference sequence; B is gene ...

    Sequencing profiles of two novel variants identified in the ARG1 gene ...

    Sequencing profiles of two novel variants identified in the ARG1 gene ...

    Sequencing profiles of two novel variants identified in the ARG1 gene ...

    Sequencing profiles of two novel variants identified in the ARG1 gene ...

    ARG1 gene deletion strategy using completely heterologous antibiotic ...

    ARG1 gene deletion strategy using completely heterologous antibiotic ...

    Arginase 1 gene and protein expression in the whole tumour and single ...

    Arginase 1 gene and protein expression in the whole tumour and single ...

    ARG1 activity and gene expression are related to malignancy in human ...

    ARG1 activity and gene expression are related to malignancy in human ...

    Summary of the reported mutation in the ARG1 gene. | Download ...

    Summary of the reported mutation in the ARG1 gene. | Download ...

    A) ARG1 gene structure. White and shaded boxes indicate UTRs and coding ...

    A) ARG1 gene structure. White and shaded boxes indicate UTRs and coding ...