baicalin

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      As baicalin is a flavone glycoside, it is a flavonoid. It is the glucuronide of baicalein.


      Natural occurrences


      Baicalin is found in several species in the genus Scutellaria, including Scutellaria baicalensis, and Scutellaria lateriflora. There are 10 mg/g baicalin in Scutellaria galericulata leaves. It is also present in the bark isolate of the Oroxylum indicum tree.


      Medical uses


      Baicalin is one of the chemical ingredients of at least two herbal supplements: Shuanghuanglian and Sho-Saiko-To, which is a Chinese classic herbal formula, and listed in Japan as Kampo medicine.
      Baicalin, along with its aglycone baicalein, is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABAA receptor. In mice, baicalin produces anxiolytic effects without sedative or myorelaxant effects. It is thought that baicalin, along with other flavonoids, may underlie the anxiolytic effects of S. baicalensis and S. lateriflora.
      Baicalin is a known prolyl endopeptidase inhibitor. It induces apoptosis in pancreatic cancer cells.


      References

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    baicalin

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    Baicalin - Wikipedia

    Baicalin, along with its aglycone baicalein, is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABA A receptor. [3] [4] [5] In mice, baicalin …

    An overview of pharmacological activities of baicalin and its …

    In this review, we highlighted the signaling pathways of baicalin and baicalein in the treatment and chemoprevention anti-cancer, anti-inflammatory, antioxidative and cytoprotective properties as …

    Potential therapeutic effects of baicalin and baicalein - PMC

    Baicalin and baicalein are natural flavonoids reported for the first time from Scutellaria baicalensis Georgi. Recently, attention has been paid to these valuable flavonoids due to their promising …

    Baicalin & Baicalein: Potential Benefits & Upcoming Research

    Aug 20, 2023 · Baicalin and baicalein are flavones under investigation for potential benefits to the nervous system & in rheumatoid arthritis. Learn more here. What are Baicalin and Baicalein?

    Baicalein - Wikipedia

    Baicalein, along with its glucuronide baicalin, is a positive allosteric modulator of the benzodiazepine site and a non-benzodiazepine site of the GABA A receptor, but with an …

    Baicalin | C21H18O11 | CID 64982 - PubChem

    Baicalin is the glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis.

    The Pharmacological Efficacy of Baicalin in Inflammatory Diseases

    May 26, 2023 · While baicalin is demonstrated to have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, antioxidant, hepatoprotective, and neuroprotective effects, its low …

    Baicalin: a potential therapeutic agent for acute kidney injury and ...

    Jan 22, 2025 · Baicalin, a naturally occurring compound classified within the flavonoid group and commonly found in the Chinese herb Scutellaria baicalensis, has shown a range of …

    The potential of baicalin to enhance neuroprotection and …

    Mar 19, 2024 · We found that in C8-B4 cells, baicalin at ≥ 1 μM exhibited anti-inflammatory effects, lowering TNF-α levels in the cell culture media. In NT2-N cells, baicalin positively affected …

    Baicalin - an overview | ScienceDirect Topics

    Baicalin is a flavonoid molecule derived from a Chinese medicine, huang qin. It has been a subject of extensive research in China and other countries in recent years. Previously, it was …