Cathepsin A GudangMovies21 Rebahinxxi LK21

      Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA gene. The enzyme is also known as Human Protective Protein. It is a lysosomal serine carboxypeptidase. The enzyme is a zymogen and must be processed to produce a 32 kDa and 20 kDa large and small subunit, respectively, to become catalytically active. Cathespin L can activate Cathepsin A in vitro.


      Structure


      Cathepsin A contains a large and small subunit. The active site contains unusual pairs of carboxylic acids hydrogen bonded to one another, sometimes referred to as "Rebek pairs".

      The pairing of these carboxylic acids raises the pKa of one glutamate to ~13 while the other has a predicted pKa of ~6.


      Function


      This gene encodes a glycoprotein that associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high-molecular-weight multimers. The formation of this complex provides a protective role for stability and activity. It is protective for β-galactosidase and neuraminidase.


      Substrates


      CTSA is part of the Renin Angiotensin System (RAS). Substrates of the enzyme that have been identified in vitro include endothelin I, angiotensin I, bradykinin, Substance P, and oxytocin.


      Inhibition


      Cathepsin A is one of 14 human enzymes commonly inhibited by organophosphate pesticides and phosphonate nerve agents. Cathepsin A can be inhibited by sarin, soman, cyclosarin, VX, and VR. After inhibition, it undergoes aging. The enzyme can be found in urine and blood.


      Clinical significance


      Deficiencies in this gene are linked to multiple forms of galactosialidosis and CARASAL.


      Interactions


      Cathepsin A has been shown to interact with NEU1 and GLB1.


      References




      Further reading




      External links


      Cathepsin+A at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

    Kata Kunci Pencarian:

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    Cathepsin-D | NeuroScience Associates

    Cathepsin-D | NeuroScience Associates

    Cathepsin B - Alchetron, The Free Social Encyclopedia

    Cathepsin B - Alchetron, The Free Social Encyclopedia

    Cathepsin A - Wikipedia

    Cathepsin A - Wikipedia

    176 Cathepsin Images, Stock Photos & Vectors | Shutterstock

    176 Cathepsin Images, Stock Photos & Vectors | Shutterstock

    Cathepsin-enzyme

    Cathepsin-enzyme

    Cathepsin X-IN-1 | C15H13N3O3S | CID 162654727 - PubChem

    Cathepsin X-IN-1 | C15H13N3O3S | CID 162654727 - PubChem

    Cathepsin C-IN-5 | C21H17ClN6OS | CID 163409160 - PubChem

    Cathepsin C-IN-5 | C21H17ClN6OS | CID 163409160 - PubChem

    Cathepsin L Antibodies: Novus Biologicals

    Cathepsin L Antibodies: Novus Biologicals

    Cathepsin C Protein Overview | Sino Biological

    Cathepsin C Protein Overview | Sino Biological

    Cathepsin D - scrippslabs.com

    Cathepsin D - scrippslabs.com

    Cathepsin K Protein Overview | Sino Biological

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    APExBIO - Cathepsin S inhibitor|Blocks MHCII antigen presentation |CAS ...

    APExBIO - Cathepsin S inhibitor|Blocks MHCII antigen presentation |CAS ...

    Search Results

    cathepsin a

    Daftar Isi

    Cathepsin A - Wikipedia

    Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA gene. [5] The enzyme is also known as Human Protective Protein. It is a lysosomal serine carboxypeptidase. The enzyme is a zymogen and must be processed to produce a 32 kDa and 20 kDa large and small subunit, respectively ...

    Cathepsin A/protective protein: an unusual lysosomal ... - PubMed

    Molecular cloning and gene expression studies have disclosed that protective protein is cathepsin A. The cathepsin A precursor has the potential to restore both beta-galactosidase and neuraminidase activities in fibroblasts from patients with galactosialidosis.

    Lysosomal Cathepsin A Plays a Significant Role in the …

    Lysosomal serine carboxypeptidase Cathepsin A (CTSA) is a multifunctional enzyme with distinct protective and catalytic function. CTSA present in the lysosomal multienzyme complex to facilitate the correct lysosomal routing, stability and activation of …

    Cathepsin A - an overview | ScienceDirect Topics

    Cathepsin A is a multifunctional enzyme containing deamidase, esterase and carboxypeptidase activities [92]. Human genetic defects in cathepsin A lead to a lysosomal storage disorder (galactosialidosis) accompanied by secondary deficiency of β …

    Cathepsin A: Enzymatic Functions and Structural Insights

    Jan 14, 2025 · Cathepsin A is a lysosomal enzyme with diverse roles in cellular metabolism and protein regulation. Its significance extends beyond basic enzymatic functions, impacting various physiological processes and contributing to cellular homeostasis. Understanding Cathepsin A’s functionalities offers insights into broader cellular mechanisms.

    The Ins and Outs of Cathepsins - PubMed Central (PMC)

    In this review, we summarize the available evidence regarding the role of cathepsins in health and disease, discuss their potential as biomarkers of disease progression, and shed light on the potential of extracellular cathepsin inhibitors as safe therapeutic tools.

    Jul 3, 2024 · Cathepsin A-related arteriopathy with strokes and leukoencephalopathy (CARASAL) is a very rare monogenic autosomal dominant cerebral small vessel disease.

    Cathepsin - Wikipedia

    Cathepsins (Ancient Greek kata- "down" and hepsein "boil"; abbreviated CTS) are proteases (enzymes that degrade proteins) found in all animals as well as other organisms. There are approximately a dozen members of this family, which are distinguished by their structure, catalytic mechanism, and which proteins they cleave [citation needed].

    Lysosomal Protective Protein/Cathepsin A - Journal of Biological Chemistry

    Lysosomal protective protein/cathepsin A is a serine carboxypeptidase that forms a complex with β-galactosidase and neuraminidase. The enzyme is synthesized as a 54-kDa precursor/zymogen and processed into a catalytically active 32- and 20-kDa two-chain form.

    Prognostic significance and oncogene function of cathepsin A in ...

    Jul 16, 2021 · Cathepsin A (CTSA) is a lysosomal protease that regulates galactoside metabolism. The previous study has shown CTSA is abnormally expressed in various types of cancer. However, rarely...