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Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.
Interactions
Cadherin-4 has been shown to interact with:
PTPmu
References
Further reading
External links
CDH4 human gene location in the UCSC Genome Browser.
CDH4 human gene details in the UCSC Genome Browser.
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CDH4 - Wikipedia
Cadherin-4 is a protein that in humans is encoded by the CDH4 gene. [5][6][7] This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent …
CDH4 Gene - GeneCards | CADH4 Protein | CADH4 Antibody
24 Des 2024 · CDH4 (Cadherin 4) is a Protein Coding gene. Diseases associated with CDH4 include Hepatocellular Carcinoma and Seckel Syndrome. Among its related pathways are Cell …
1002 - Gene ResultCDH4 cadherin 4 [ (human)] - National Center …
Cdh4 regulates cell proliferation, cell migration and tumorigenic potential of patient derived glioblastoma cells. High CDH4 expression is associated with triple-negative breast cancer. …
CDH4 cadherin 4 [Homo sapiens (human)] - Gene - NCBI
10 Des 2024 · Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney …
Understanding the Role of CDH4 in Multiple System Atrophy Brain
Firstly, we found that CDH4 in MSA brain was significantly elevated in the disease-affected motor cortex white matter in MSA (N = 11) compared to controls (N = 13) and unaltered in the …
CDH4 cadherin 4 - NIH Genetic Testing Registry (GTR) - NCBI
Cadherin switches during epithelial-mesenchymal transition: CDH4/RCAD downregulation reduces bladder cancer progression. Regulatory CDH4 Genetic Variants Associate With Risk …
CDH4 protein expression summary - The Human Protein Atlas
RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different …
CDH4 is a novel determinant of osteosarcoma tumorigenesis and ...
03 Apr 2018 · Gain or loss-of-function of CDH4, which encodes R-cadherin, causally impacts multiple features of human OS cells including cell migration and invasion, osteogenic …
CDH4 inhibits ferroptosis in oral squamous cell carcinoma cells
High expression of CDH4 effectively promotes the proliferation, mobility of OSCC cells and reduce the sensitivity of OSCC cells to ferroptosis.
Expression and Prognostic Significance of Cadherin 4 (CDH4) in …
In the present study, we assessed the expression characteristics of CDH4 in RCC in contrast to normal kidney tissues and evaluated their utility in RCC diagnosis and prognosis.