Artikel: COP9 constitutive photomorphogenic homolog subunit 5 GudangMovies21 Rebahinxxi

  • Source: COP9 constitutive photomorphogenic homolog subunit 5

    • 5.180.24.3/?s=cop9" target="_blank">COP9 5.180.24.3/?s=constitutive" target="_blank">constitutive 5.180.24.3/?s=photomorphogenic" target="_blank">photomorphogenic 5.180.24.3/?s=homolog" target="_blank">homolog 5.180.24.3/?s=subunit" target="_blank">subunit 5 (Arabidopsis), also known as COPS5 or Csn5, is a gene conserved from humans to Saccharomyces cerevisiae.


    Function


    The protein encoded by this gene is one of the eight subunits of 5.180.24.3/?s=cop9" target="_blank">COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of 5.180.24.3/?s=cop9" target="_blank">COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. 5.180.24.3/?s=cop9" target="_blank">COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors.


    Interactions


    5.180.24.3/?s=cop9" target="_blank">COP9 5.180.24.3/?s=constitutive" target="_blank">constitutive 5.180.24.3/?s=photomorphogenic" target="_blank">photomorphogenic 5.180.24.3/?s=homolog" target="_blank">homolog 5.180.24.3/?s=subunit" target="_blank">subunit 5 has been shown to interact with Macrophage migration inhibitory factor, GFER, BCL3, Ubiquitin carboxy-terminal hydrolase L1, S100A7 and C-jun.


    See also


    COPS1
    COPS2
    COPS3
    COPS4
    COPS6
    COPS7A
    COPS7B
    COPS8


    References




    External links


    Human COPS5 genome location and COPS5 gene details page in the UCSC Genome Browser.


    Further reading

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