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Cryspovirus GudangMovies21 Rebahinxxi LK21

Cryspovirus is a genus of viruses, in the family Partitiviridae. Protists serve as natural hosts. There is only one species in this genus: Cryptosporidium parvum virus 1.
Cryptosporidium, a genus of Apicomplexan parasites, is known to cause human diarrheal
illness. A bi-segmented dsRNA virus linked with Cryptosporidium was discovered and
found to have similarities with picobirnaviruses and partitiviruses. This discovery led to the
identification of a distinct virus called Cryptosporidium parvum virus 1 (CSpV1). It was
suggested to be the sole partitivirus found in a protozoan host. Based on this, a new genus
named Cryspovirus was proposed within the Partitiviridae family, which was subsequently
approved by the ICTV Executive Committee in 2009. CSpV1, also known as Cryspovirus, is
believed to be transmitted intracellularly through Cryptosporidium oocysts and is linked with
persistent, mostly non-virulent infections. The virus features isometric virions and has a genome
composed of two separate dsRNA molecules encoding RdRp and CP. Notably, the CP of
CSpV1 is smaller than that of other partitiviruses, indicating a unique capsid structure.
Biologically, CSpV1 appears to be primarily transmitted through intracellular methods and is
associated with non-aggressive infections. Its impact on altering Cryptosporidium's
pathogenicity remains to be fully understood. CSpV1 exhibits unique genomic and coding
characteristics, with its dsRNA segments having distinct nucleotide sequences (often detected
via PCR). The virus is believed to employ a non-standard mechanism for translation, and
conserved sequences at the 3′ ends of its dsRNAs might be involved in replication or packaging
processes. CSpV1 holds practical significance in the detection of Cryptosporidium in
contaminated water supplies and in the epidemiological monitoring of Cryptosporidium
infections.