demodicosis

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      Demodicosis , also called Demodex folliculitis in humans and demodectic mange () or red mange in animals, is caused by a sensitivity to and overpopulation of Demodex spp. as the host's immune system is unable to keep the mites under control.
      Demodex is a genus of mite in the family Demodecidae. The mites are specific to their hosts, and each mammal species is host to one or two unique species of Demodex mites. Therefore, demodicosis cannot be transferred across species and has no zoonotic potential.


      Signs and symptoms




      = Humans

      =

      Demodicosis in humans is usually caused by Demodex folliculorum and may have a rosacea-like appearance. Common symptoms include hair loss, itching, and inflammation. An association with pityriasis folliculorum has also been described.
      Demodicosis is most often seen in folliculitis (inflammation of the hair follicles of the skin). Depending on the location, it may result in small pustules (pimples) at the base of a hair shaft on inflamed, congested skin. Demodicosis may also cause itching, swelling, and erythema of the eyelid margins. Scales at the base of the eyelashes may develop. Typically, patients complain of eyestrain.


      = Dogs

      =

      Minor cases of demodectic mange usually do not cause much itching but might cause pustules, redness, scaling, leathery skin, hair loss, skin that is warm to the touch, or any combination of these. It most commonly appears first on the face, around the eyes, or at the corners of the mouth, and on the forelimbs and paws. It may be misdiagnosed as a "hot spot" or other skin ailment.
      In the more severe form, hair loss can occur in patches all over the body and might be accompanied by crusting, pain, enlarged lymph nodes, and deep skin infections.
      Typically, animals become infected through nursing from their mother. The transmission of these mites from mother to pup is normal (which is why the mites are normal inhabitants of the dog's skin), but some individuals are sensitive to the mites due to a cellular immune deficiency, underlying disease, stress, or malnutrition, which can lead to the development of clinical demodectic mange.
      Some breeds appear to have an increased risk of mild cases as young dogs, including the Afghan Hound, American Staffordshire Terrier, Boston Terrier, Boxer, Chihuahua, Chow Chow, Shar-Pei, Collie, Dalmatian, Doberman Pinscher, Bulldog, French Bulldog, English Bull Terrier, Miniature Bull Terrier, German Shepherd, Great Dane, Old English Sheepdog, American Pit Bull Terrier, West Highland White Terrier, Rat Terrier, Yorkshire Terrier, Dachshund, and Pug.


      = Cats

      =
      There are two types of demodectic mange in cats. Demodex cati causes follicular mange, similar to that seen in dogs, though it is much less common. Demodex gatoi is a more superficial form of mange, causes an itchy skin condition, and is contagious amongst cats.


      = Other

      =
      Demodectic mange also occurs in other domestic and wild animals, including captive pandas.


      Diagnosis




      = Dogs

      =
      For demodectic mange, properly performed deep skin scrapings generally allow the veterinarian to identify the microscopic mites. The demodex mite is rarely found on clinically normal dogs, meaning that the presence of any number of mites in a sample is very likely to be significant. Acetate tape impression of the skin is another method to identify mites. In breeds such as the West Highland White Terrier, relatively minor skin irritation which would otherwise be considered allergy should be carefully scraped because of the predilection of these dogs to demodectic mange. Skin scrapings may be used to follow the progress of treatment in demodectic mange.
      Alternatively, plasma levels of zinc and copper have been seen to be decreased in dogs with demodicosis. This may be due to inflammation involved in the immune response of demodicosis which can lead to oxidative stress, resulting in dogs with demodicosis to exhibit higher levels of antioxidant productivity. The catalases involved in the antioxidant pathway require the trace minerals zinc and copper. Dogs with demodicosis show a decrease in plasma copper and zinc levels due to the increased demand for antioxidant activity. Therefore, this may be considered as a potential marker for demodicosis.


      Treatment




      = Dogs

      =
      Localized demodectic mange is considered a common puppyhood ailment, with roughly 90% of cases resolving on their own with no treatment. Minor, localized cases should be left to resolve on their own to prevent masking of the more severe generalized form. If treatment is deemed necessary, Goodwinol, a rotenone-based insecticide ointment, is often prescribed, but it can be irritating to the skin. Demodectic mange with secondary infection is treated with antibiotics and medicated shampoos.
      For more severe generalized cases, Amitraz is a parasiticidal dip that is licensed for use in many countries (the only FDA approved treatment in the USA) for treating canine demodicosis. It is applied weekly or biweekly for several weeks, until no mites can be detected by skin scrapings. Demodectic mange in dogs can also be managed with avermectins, although there are few countries which license these drugs, which are given by mouth daily, for this use. Ivermectin is used most frequently; collie-like herding breeds often do not tolerate this drug due to a defect in the blood–brain barrier, though not all of them have this defect. Other avermectin drugs that can be used include doramectin and milbemycin.
      Recent results suggest that the isoxazolines afoxolaner and fluralaner, given orally, are effective in treating dogs with generalized demodicosis.
      Because of the possibility of the immune deficiency being an inherited trait, many veterinarians believe that all puppies with generalized demodex should be spayed or neutered and not reproduce. Females with generalized demodex should be spayed because the stress of the estrus cycle will often bring on a fresh wave of clinical signs.


      = Cats

      =
      Cats with Demodex gatoi must be treated with weekly or bi-weekly sulfurated lime rinses. Demodex cati are treated similarly to canine demodicosis. With veterinary guidance, localized demodectic mange can also be treated with a topical keratolytic and antibacterial agent, followed by a lime sulfur dip or a local application of Rotenone. Ivermectin may also be used. Generalized demodectic mange in cats is more difficult to treat. There are shampoos available that can help to clear dead skin, kill mites and treat bacterial infections. Treatment is in most cases prolonged with multiple applications.


      References




      External links

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    Demodex, demodicosis - DermNet

    Dec 28, 2016 · Demodicosis results in non-specific symptoms and signs on facial skin. These most often include: Follicular scales; Redness; Sensitive skin; Itch. Macules, papules, eczema, folliculitis and pigmentation have also been described. Patients with demodicosis may have eye irritation, itching and scaling of eyelids (blepharitis or eyelid dermatitis).

    Demodicosis pathology - DermNet

    Demodicosis is caused by two species of follicular mites, Demodex folliculorum and Demodex brevis, which are normal inhabitants of human skin. Although the mites are ubiquitous on sebaceous-rich skin, they sometimes cause dermal reaction and consequent erythema, pustules, and inflammatory plaques. Histology of demodicosis

    Demodicosis image - DermNet

    IMPORTANT NOTICE: DermNet does not provide a free online consultation service. If you have any concerns with your skin or its treatment, see a dermatologist for advice.

    demodex image - DermNet

    Demodex is the name given to tiny mites that live in the hair follicle. In humans, demodex is found on facial skin, especially the forehead, cheeks, sides of the nose, eyelashes and external ear canals. It sometimes causes a condition called demodicosis. Read more

    Rosacea due to demodicosis image - DermNet

    IMPORTANT NOTICE: DermNet does not provide a free online consultation service. If you have any concerns with your skin or its treatment, see a dermatologist for advice.

    Folliculitis - DermNet

    This is known as demodicosis. The human infestation, scabies, often provokes folliculitis, as well as non-follicular papules, vesicles and pustules. Folliculitis due to irritation from regrowing hairs. Folliculitis may arise as hairs regrow after shaving, waxing, electrolysis, or plucking.

    Ivermectin - DermNet

    Ivermectin can also be used to control demodicosis. Ivermectin cream has been shown to reduce papulopustular rosacea, which is thought to be due to its effects on demodex mites and its anti-inflammatory action. A 2021 Cochrane Review has not found sufficient evidence to support the use of ivermectin for preventing or treating COVID-19.

    Rosacea: Symptoms, Causes, and Management - DermNet

    Demodicosis (demodex folliculitis) Dermatomyositis; Drug reaction; Eczema; Idiopathic facial aseptic granuloma; Periorificial dermatitis or periocular dermatitis; Photo-damaged skin; Pyoderma faciale; Seborrhoeic dermatitis; Steroid-induced acne; Steroid-induced rosacea; Systemic lupus erythematosus. What is the treatment for rosacea?

    Pustular skin conditions - DermNet

    Bibliography. Bachelez H. Pustular psoriasis and related pustular skin diseases. Br J Dermatol. 2018;178(3):614-18. doi:10.1111/bjd.16232 PubMed

    Facial skin problems - DermNet

    Demodicosis; Dermatitis; Discoid lupus erythematosus; Dry skin; Eczema; Elastolytic giant cell granuloma; Erythema dyschromicum perstans; Facial discoid dermatosis; Flushing; Folliculitis barbae; Granuloma faciale; Hair follicle tumours; Idiopathic facial aseptic granuloma; Jessner lymphocytic infiltrate; Keratosis pilaris atrophicans faciei ...