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Deprenyl, also known by its developmental code name E-250 and as N-propargylmethamphetamine, is the racemic mixture of D-deprenyl and L-deprenyl (selegiline). It was discovered in 1961 in Hungary at Chinoin Pharmaceutical Company by Zoltan Ecseri and József Knoll, was patented in 1962, and was first described in the literature in 1964 or 1965.
The drug is a monoamine oxidase inhibitor and norepinephrine–dopamine releasing agent. It is a prodrug of methamphetamine and amphetamine, which mediates the latter action. Deprenyl was studied clinically at high doses of 50 to 100 mg/day and was described as a psychostimulant and antidepressant. At lower doses, selective MAO-B inhibition would be expected, but at these higher doses, dual inhibition of MAO-A and MAO-B would occur, on the basis of L-deprenyl.
Subsequent to its synthesis, the stereoisomers of deprenyl were separated. The dextrorotatory isomer, D-deprenyl, was found to be more toxic, producing effects like hyperthermia and more potent psychostimulation in rodents. The levorotatory isomer, selegiline, was much more potent as an MAO-B inhibitor, and was subsequently developed for the treatment of Parkinson's disease and depression.
Deprenyl is reported to result in side effects including agitation, anxiety, and sleep disturbances more often than selegiline.
Similarly to selegiline, deprenyl is a catecholaminergic activity enhancer (CAE). Both enantiomers of deprenyl, D-deprenyl and selegiline, are active in this respect, but selegiline is slightly more potent than D-deprenyl.

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Selegiline - Wikipedia
Deprenyl - Wikipedia
Deprenyl: 50 Years of Life Enhancement and Life Extension
Deprenyl- A Multi-Functional Anti-aging Drug | Nootropics
The Discovery and History of Deprenyl: From Laboratory to …
Deprenyl (Selegiline), L-Dopa, and Parkinson's - Futurescience
Deprenyl (selegiline): the history of its development and ...
Selegiline: Uses, Interactions, Mechanism of Action - DrugBank …
Selegiline Uses, Side Effects & Warnings - Drugs.com
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Selegiline - Wikipedia

Selegiline, also known as L-deprenyl and sold under the brand names Eldepryl, Zelapar, and Emsam among others, is a medication which is used in the treatment of Parkinson's disease and major depressive disorder.

Deprenyl - Wikipedia

Deprenyl, also known by its developmental code name E-250 and as N-propargylmethamphetamine, is the racemic mixture of D -deprenyl and L -deprenyl (selegiline). [1][2][3] It was discovered in 1961 in Hungary at Chinoin Pharmaceutical Company by Zoltan Ecseri and József Knoll, was patented in 1962, and was first described in the literature in 196...

Deprenyl: 50 Years of Life Enhancement and Life Extension

Over the past half century, deprenyl has gained recognition not only as a clinically proven antidepressant and Parkinson’s treatment, but also as a mental energizer, physical and cognitive performance booster, generalized mood-lifter, sex enhancer, brain protector, and longevity tonic.

Deprenyl- A Multi-Functional Anti-aging Drug | Nootropics

Mar 26, 2019 · Deprenyl was for many years a relatively obscure drug, used only in Europe and Latin America for its officially approved indication as an adjunctive treatment for Parkinson’s disease; until a bombshell article appeared in a highly specialized, extremely limited circulation professional journal (Knoll, 1988).

The Discovery and History of Deprenyl: From Laboratory to …

Nov 1, 2024 · Explore the discovery and historical journey of Deprenyl, from its synthesis in the 1960s to its ongoing role in scientific research. Delve into the compound's unique properties, global research perspectives, and ethical considerations in production.

Deprenyl (Selegiline), L-Dopa, and Parkinson's - Futurescience

Deprenyl acts on an important chemical in the brain called dopamine. Dopamine is manufactured in the brain from two amino acids that occur naturally in foods: phenylalanine and tyrosine. To function properly, the human body requires a multitude of chemicals in well-regulated quantities.

Deprenyl (selegiline): the history of its development and ...

The most important effect of deprenyl in the brain is the sensitization of dopaminergic neurons to physiological and pharmacological influences, but in contrast to levodopa or bromocrytine, deprenyl does not elicit an acute increase in dopaminergic activity.

Selegiline: Uses, Interactions, Mechanism of Action - DrugBank …

Selegiline is a monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's. A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy.

Selegiline Uses, Side Effects & Warnings - Drugs.com

Aug 10, 2023 · Selegiline prevents the breakdown of a chemical in your brain called dopamine (DO pa meen). Low levels of this chemical are associated with Parkinson's disease. Selegiline is used together with other medicines to treat symptoms of Parkinson's disease. Selegiline may also be used for purposes not listed in this medication guide.

Deprenyl | C13H17N | CID 5195 - PubChem

Oct 14, 2021 · Deprenyl | C13H17N | CID 5195 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.