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      Dihexa (developmental code PNB-0408; also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.
      According to a patent, "Short duration safety studies with dihexa have uncovered no apparent toxicity. Of particular note is a lack of neoplastic induction, since c-Met is recognized as an oncogene. This is unsurprising since oncogenesis requires multiple mutations including both oncogene induction and tumor suppressor attenuation."


      History


      Dihexa was developed by Joseph Harding and his team at Washington State University. Later developments were done by M3 Biotechnology, a company founded to commercialize dihexa.
      Fosgonimeton, a phosphate pro-drug of dihexa is currently in clinical trials for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's disease


      References

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    Dihexa – The Supplier of Pharmaceutical Ingredients

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    Dihexa

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    DIHEXA Peptide Therapy in Phoenix | Focal Point Vitality

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    Dosing Dihexa - Brain Health - LONGECITY

    Aug 7, 2018 · Dosing Dihexa - posted in Brain Health: I am new to Longecity so please let me know if this isnt the right place to post this. Yesterday I received Dihexa solution from …

    Dihexa: "it would take 10 million times as much BDNF to get

    Oct 12, 2012 · Page 1 of 53 - Dihexa: "it would take 10 million times as much BDNF to get as much new synapse formation as Dihexa." - posted in Brain Health: "Harding, Wright, and their …

    Dihexa orally or Transdermal with DMSO? - Brain Health

    Jan 7, 2019 · Dihexa orally or Transdermal with DMSO? - posted in Brain Health: Hello, I been taking dihexa orally. Putting 30mg in a capsule then swallowing it. Then thought of why people …

    The science behind DIHEXA (function and risks) - Brain Health

    Sep 3, 2014 · Page 1 of 2 - The science behind DIHEXA (function and risks) - posted in Brain Health: Im trying to uncover how dihexa works. View on Vimeo. ^ Inventor (Harding) gives a …

    Dihexa: "it would take 10 million times as much BDNF to get

    Oct 12, 2012 · Dihexa actually seems to be orally active and BBB-penetrating on its own. The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of …

    Dihexa Experience - Brain Health - LONGECITY

    Jan 21, 2015 · Dihexa Experience - posted in Brain Health: I have been experimenting with Dihexa over the last week or so, and its definitely doing something, but Im not sure what. Below are …

    Dihexa: "it would take 10 million times as much BDNF to get as …

    Oct 12, 2012 · Page 49 of 53 - Dihexa: "it would take 10 million times as much BDNF to get as much new synapse formation as Dihexa." - posted in Brain Health: I am pleased with my …

    Dihexa oral vs sublingual. - Brain Health - LONGECITY

    Aug 15, 2020 · Dihexa oral vs sublingual. - posted in Brain Health: I have 900mg of liquid Dihexa, I was told by a very high authority you need very large doses due to low bio availability, if Im …

    Is it possible for NSI-189 and Dihexa to cancel each other out?

    Sep 26, 2015 · The pharmacokinetic barrier has recently been overcome with the synthesis of the orally active, BBB permeable analog Dihexa (N-hexanoic-tyrosine-isoleucine-(6) …

    Self administering Dihexa LOG - Brain Health - LONGECITY

    Jun 5, 2015 · Self administering Dihexa LOG - posted in Brain Health: Well the title says exactly what I am doing. I bought the dihexa from nyles on amazon. I was taking noopept before …