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Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada.
Although the mechanism of action of diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly M1, M2, M3 and M4. Hence, its actions may take place at the vestibular nuclei, where a significant excitatory input is mediated by ACh receptors, and also at the vestibular periphery where mACh receptors are expressed at efferent synapses. A series of selective mACh-receptor antagonists based on the diphenidol molecule has been synthesized, but they have not yet been the subject of clinical trials.
Synthesis
Alkylation of 1-Bromo-3-chloropropane [109-70-6] (1) with piperidine (2) gives 3-Piperidinopropyl chloride [1458-63-5] (3). The Grignard reaction of this intermediate with benzophenone [119-61-9] gives the benzhydrol and hence, Diphenidol (4).
References
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Diphenidol (oral route) - Mayo Clinic
31 Jan 2024 · Diphenidol is used to relieve or prevent nausea, vomiting, and dizziness caused by certain medical problems. Back to top. Before Using. In deciding to use a medicine, the risks …
Diphenidol - Wikipedia
Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada. Although the mechanism of action of diphenidol …
Diphenidol Advanced Patient Information - Drugs.com
23 Agu 2024 · Diphenidol is used to relieve or prevent nausea, vomiting, and dizziness caused by certain medical problems. Before using diphenidol. In deciding to use a medicine, the risks of …
Diphenidol: Uses, Interactions, Mechanism of Action - DrugBank …
13 Jun 2005 · Identification Summary. Diphenidol is an antiemetic agent used for the prevention and symptomatic treatment of nausea and vomiting associated with various conditions as …
DIPHENIDOL HCL - ORAL side effects, medical uses, and ... - MedicineNet
Consumer information about the medication DIPHENIDOL HCL - ORAL , includes side effects, drug interactions, recommended dosages, and storage information. Read more about the …
Diphenidol (Diphenidol) Oral: Uses, Dosage & Side Effects
Proper usage of Diphenidol requires strict adherence to your doctor’s orders. Do not take more, less or for a longer or shorter period of time than your doctor tells you. If you are taking this …
DIPHENIDOL HYDROCHLORIDE - National Center for …
Diphenidol, a nonphenothiazinic antiemetic agent used primarily in patients with Meniere disease and labyrinthopathies to treat vomiting and vertigo, is considered to be a relatively safe drug. …
DIPHENIDOL (PD009949, OGAKLTJNUQRZJU-UHFFFAOYSA …
DESCRIPTION Diphenidol is a muscarinic antagonist , antiemetic and antivertigo drug. ( GtoPdb ) DESCRIPTION Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with …
Diphenidol | C21H27NO | CID 3055 - PubChem
Diphenidol is a tertiary alcohol that is butan-1-ol substituted by two phenyl groups at position 1 and a piperidin-1-yl group at position 4. It has a role as an antiemetic. It has a role as an antiemetic.
Diphenidol - healthencyclopedia.org
Introduction. Diphenidol is an antiemetic and antivertigo agent used to relieve and prevent nausea, vomiting, and dizziness associated with various medical problems. This …