Fisetin | C15H10O6 - ChemSpider
ChemSpider record containing structure, synonyms, properties, vendors and database links for Fisetin, 528-48-3, Fustel, XHEFDIBZLJXQHF-UHFFFAOYSA-N.
- Source: Fisetin
- Flavona
- Fisetin
- Toxicodendron succedaneum
- Senolytic
- Cotinus coggygria
- Fustic
- Bcl-xL
- Quercitron
- Quercetin
- Myricetin
- Glucoside
fisetin
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Fisetin (7,3′,4′-flavon-3-ol) is a plant flavonol from the flavonoid group of polyphenols. It occurs in many plants where it serves as a yellow pigment. It is found in many fruits and vegetables, such as strawberries, apples, persimmons, onions, and cucumbers.
Its chemical formula was first described by Austrian chemist Josef Herzig in 1891.
Sources
Fisetin occurs in many plants, such as the trees and shrubs of Fabaceae, acacias Acacia greggii, and Acacia berlandieri, parrot tree (Butea frondosa), honey locust (Gleditsia triacanthos), members of the family Anacardiaceae such as the Quebracho colorado, and species of the genus Rhus, which contains the sumacs. Along with myricetin, fisetin provides the color of the traditional yellow dye young fustic, an extract from the Eurasian smoketree (Rhus cotinus).
Many fruits and vegetables contain fisetin. In one study, fisetin content was highest in strawberries, with content also observed in apples, grapes, onions, tomatoes, and cucumbers. Fisetin can be extracted from fruit juices, wines, and teas. It is also present in Pinophyta species such as the yellow cypress (Callitropsis nootkatensis).
The average intake of fisetin from foods in Japan is about 0.4 mg per day.
Biosynthesis
Fisetin is a flavonoid, which is a polyphenol subgroup. Flavonoid synthesis begins with the phenylpropanoid pathway, in which phenylalanine, an amino acid, is transformed into 4-coumaroyl-CoA. This is the compound that enters the flavonoid biosynthesis pathway. Chalcone synthase, the first enzyme of this pathway, produces chalcone from 4-coumaroyl-CoA. All flavonoids are derived from this chalcone backbone (this family being the so-called chalconoids). The activity of different enzymes, including isomerases and hydroxylases, alter the backbone depending on the subclass of the flavonoid being produced.
Research
Although fisetin has been under laboratory research over several decades for its potential role in senescence or anticancer properties, among other possible effects, there is no clinical evidence that it provides any benefit to human health, as of 2018.
References
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Artikel Terkait "fisetin"
Fisetin: A Senolytic Antioxidant for Healthy Aging & More - Dr. Axe
26 Sep 2020 · Fisetin is a plant pigment and antioxidant that has gained attention because of its senolytic properties. The flavonoid is known for its ability to prevent the replication of damaged DNA, thereby reducing the risk of aging, degenerative disease, heart disease and cancer.
Fisetin - Wikipedia
Fisetin (7,3′,4′- flavon-3-ol) is a plant flavonol from the flavonoid group of polyphenols. [1] It occurs in many plants where it serves as a yellow pigment. It is found in many fruits and vegetables, such as strawberries, apples, persimmons, onions, and cucumbers. [2][3][4]
Fisetin Benefits: Dosages and How to Take It
04 Jun 2024 · In addition to its senolytic effects, fisetin’s health benefits include antioxidant, anti-inflammatory, anti-cancer, and brain-boosting action, making it a top contender in the longevity supplement space.
Fisetin: Benefits, Dosage, Side Effects, Drug Interactions, and …
28 Jan 2025 · Fisetin is a naturally occurring flavonoid with a potential role in increasing alertness, concentration, and cognition. This page intends to provide a thorough analysis of Fisetin, including its chemical structure, physiological mode of action, health advantages, ideal dosage, potential side effects, and drug interactions, for anyone interested ...
Fisetin: Benefits, Side-Effects, Dosage and Research
30 Sep 2022 · Fisetin is one such flavonoid found in many fruits and vegetables, including apples, peppers, tomatoes and onions. It might not be the most popular flavonoid out there, but it has …
Fisetin: A Dietary Antioxidant for Health Promotion - PubMed …
Fisetin (3,3′,4′,7-tetrahydroxyflavone, Figure 1) is a bioactive flavonol molecule found in fruits and vegetables such as strawberry, apple, persimmon, grape, onion, and cucumber at concentrations in the range of 2–160 μg/g (4).
Fisetin Benefits and Side Effects: A Comprehensive Overview
Fisetin is a natural flavonoid found in many fruits and vegetables. It has attracted attention for its potential health benefits. Research has indicated that fisetin may have positive effects on various chronic diseases.
Fisetin is a senotherapeutic that extends health and lifespan
11 Jul 2018 · Fisetin reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity. Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.
What Is Fisetin Good For? - Life Extension
20 Jan 2021 · Fisetin is a compound found in several fruits and vegetables, including strawberries, apples, grapes, and onions. Fisetin is the most potent senolytic compound found among a panel of flavonoids, selectively removing senescent cells and extending longevity in animal studies.
Fisetin Supplement: Mechanisms, Benefits, and Clinical Findings ...
28 Jun 2024 · Fisetin supplements have demonstrated potential in promoting healthy aging, improving brain function, and reducing the risk of several chronic diseases, including cancer and heart disease. As part of my research, I’ve delved into the antioxidative and anti-inflammatory properties of fisetin.