Fusidic acid GudangMovies21 Rebahinxxi LK21
Fusidic acid, sold under the brand name Fucidin among others, is a steroid antibiotic that is often used topically in creams or ointments and eyedrops but may also be given systemically as tablets or injections. As of October 2008, the global problem of advancing antimicrobial resistance has led to a renewed interest in its use.
Medical uses
Fusidic acid is active in vitro against Staphylococcus aureus, most coagulase-positive staphylococci, Beta-hemolytic streptococci, Corynebacterium species, and most clostridium species. Fusidic acid has no known useful activity against enterococci or most Gram-negative bacteria (except Neisseria, Moraxella, Legionella pneumophila, and Bacteroides fragilis). Fusidic acid is active in vitro and clinically against Mycobacterium leprae but has only marginal activity against Mycobacterium tuberculosis.
One use of fusidic acid is its activity against methicillin-resistant Staphylococcus aureus (MRSA). Although many strains of MRSA remain sensitive to fusidic acid, there is a low genetic barrier to drug resistance (a single point mutation is all that is required), fusidic acid should never be used on its own to treat serious MRSA infection and should be combined with another antimicrobial such as rifampicin when administering oral or topical dosing regimens approved in Europe, Canada, and elsewhere. However, resistance selection is low when pathogens are challenged at high drug exposure.
Topical fusidic acid is occasionally used as a treatment for acne vulgaris. As a treatment for acne, fusidic acid is often partially effective at improving acne symptoms. However, research studies have indicated that fusidic acid is not as highly active against Cutibacterium acnes as many other antibiotics that are commonly used as acne treatments. Fusidic acid is also found in several additional topical skin and eye preparations (e.g., Fucibet), although its use for these purposes is controversial.
Side effects
Fucidin tablets and suspension, whose active ingredient is sodium fusidate, occasionally cause liver damage, which can produce jaundice (yellowing of the skin and the whites of the eyes). This condition will almost always get better after the patient finishes taking Fucidin tablets or suspension. Other related side-effects include dark urine and lighter-than-usual feces. These, too, should normalize when the course of treatment is completed.
Pharmacology
Fusidic acid acts as a bacterial protein synthesis inhibitor by preventing the turnover of elongation factor G (EF-G) from the ribosome. Fusidic acid is effective primarily on Gram-positive bacteria such as Staphylococcus, Streptococcus and Corynebacterium species.
Fusidic acid is a tetracyclic, naturally occurring steroid derived from the fungus Fusidium coccineum. It was first isolated in 1960 and developed by Leo Pharma in Ballerup, Denmark, being used clinically from 1962 onwards. It has also been isolated from Mucor ramannianus, an Acremonium species, and Isaria kogana. The drug is licensed for use as its sodium salt sodium fusidate, and it is approved for use under prescription in Australia, Canada, Colombia, the European Union, India, Japan, New Zealand, South Korea, Taiwan, Thailand, and the United Kingdom.
Mechanism of action
Fusidic acid binds to EF-G after translocation and GTP (guanosine-5'-triphosphate) hydrolysis. This interaction prevents the necessary conformational changes for EF-G release from the ribosome, effectively blocking the protein synthesis process. Fusidic acid can only bind to EF-G in the ribosome after GTP hydrolysis.
Since translocation is a part of elongation and ribosome recycling, fusidic acid can block either or both steps of protein synthesis.
Dose
Fusidic acid should not be used on its own to treat S. aureus infections when used at low drug dosages. However, it may be possible to use fusidic acid as monotherapy when used at higher doses.
The use of topical preparations (skin creams and eye ointments) containing fusidic acid is strongly associated with the development of resistance, and there are voices advocating against the continued use of fusidic acid monotherapy in the community. Topical preparations used in Europe often contain fusidic acid and gentamicin in combination, which helps to prevent the development of resistance.
= Cautions
=
There is inadequate evidence of safety in human pregnancy. Animal studies and many years of clinical experience suggest that fusidic acid is devoid of teratogenic effects (birth defects), but fusidic acid can cross the placental barrier.
Resistance
In vitro susceptibility studies of US strains of several bacterial species such as S. aureus, including MRSA and coagulase negative Staphylococcus, indicate potent activity against these pathogens.
Mechanisms of resistance have been extensively studied only in Staphylococcus aureus. The most studied mechanism is the development of point mutations in fusA, the chromosomal gene that codes for EF-G. The mutation alters EF-G so that fusidic acid is no longer able to bind to it. Resistance is readily acquired when fusidic acid is used alone and commonly develops during the course of treatment. As with most other antibiotics, resistance to fusidic acid arises less frequently when used in combination with other drugs. For this reason, fusidic acid should not be used on its own to treat serious Staph. aureus infections. However, at least in Canadian hospitals, data collected between 1999 and 2005 showed rather low rate of resistance of both methicillin-susceptible and methicillin-resistant to fusidic acid, and mupirocin was found to be the more problematic topical antibiotic for the aforementioned conditions.
Some bacteria also display 'FusB-type' resistance, which has been found to be the most prevalent in Staphylococcus spp. in many clinical isolates. This resistance mechanism is mediated by fusB, fusC, and fusD genes found primarily on plasmids, but have also been found in chromosomal DNA. The product of fusB-type resistance genes is a 213-residue cytoplasmic protein which interacts in a 1:1 ratio with EF-G. FusB-type proteins bind in a region distinct from fusidic acid to induce a conformational change which results in liberation of EF-G from the ribosome, allowing the elongation factor to participate in another round of ribosome translocation.
Interactions
Fusidic acid should not be used with quinolone antibiotics, with which it is antagonistic. Although clinical practice over the past decade has supported the combination of fusidic acid and rifampicin, a recent clinical trial showed that there is an antagonistic interaction when both antibiotics are combined.
On 8 August 2008, it was reported that the Irish Medicines Board was investigating the death of a 59-year-old Irish man who developed rhabdomyolysis after combining atorvastatin and fusidic acid, and three similar cases. In August 2011, the UK's Medicines and Healthcare products Regulatory Agency issued a Drug Safety Update warning that "systemic fusidic acid (Fucidin) should not be given with statins because of a risk of serious and potentially fatal rhabdomyolysis."
Society and culture
= Brand names and preparations
=
Research
An orally administered mono-therapy with a high loading dose is under development in the United States.
A different oral dosing regimen, based on the compound's pharmacokinetic/pharmacodynamic (PK-PD) profile is in clinical development in the US. as Taksta.
Fusidic acid is being tested for indications beyond skin infections. There is evidence from compassionate use cases that fusidic acid may be effective in the treatment of patients with prosthetic joint-related chronic osteomyelitis.
Biosynthesis
The biosynthetic machinery in Fusidium coccineum (also known as Acremonium fusidioides) has been sequenced and analyzed. (3S)-2,3-oxidosqualene and fusidane are two intermediates.
References
External links
Kata Kunci Pencarian:
fusidic acidfusidic acid untuk bisulfusidic acid untuk jerawatfusidic acid patenfusidic acid untuk bayifusidic acid untuk lukafusidic acid hargafusidic acid paten salepfusidic acid golongan apafusidic acid generik
Fusidic acid | SIELC Technologies
Fusidic Acid - Pyfa Group
Fusidic acid | CAS NO.:6990-06-3 | GlpBio
Fusidic Acid Cas 6990-06-3 Price,Supplier from Bolise
Fusidic Acid Manufacturer from Mumbai
99.5% Fusidic Acid API | Manufacturer | Supplier
Fusidic Acid - Manufacturer,Exporter
Fusidic Acid | Uses, Brand Names, Mechanism Of Action
Fusidic acid at The Medical Dictionary
CAS 6990-06-3 Fusidic Acid Impurity | Impurity Manufacturers ...
Fusidic Acid Sodium-susceptibility testing-TOKU-E
Fusidic Acid Supplier | CAS 6990-06-3| AOBIOUS
Search Resultsfusidic acid
Daftar Isi
Fusidic acid - Wikipedia
Fusidic acid, sold under the brand name Fucidin among others, is a steroid antibiotic that is often used topically in creams or ointments and eyedrops but may also be given systemically as tablets or injections.
Fusidic acid: antibiotic to treat bacterial skin and eye infections
Find out how fusidic acid treats skin and eye infections and how to take it. NHS medicines information on fusidic acid – what it's used for, side effects, dosage and who can take it.
Fusidic acid is a substance that is used to treat bacterial infections. It will not work for colds, flu, or other virus infections. Fusidic acid is available only with your doctor's prescription.
Fusidic acid (oral route, injection route) - Mayo Clinic
Fusidic acid is a substance that is used to treat bacterial infections. It will not work for colds, flu, or other virus infections. Fusidic acid is available only with your doctor's prescription.
Fusidic acid: Uses, Interactions, Mechanism of Action - DrugBank …
Fusidic acid is a bacteriostatic antibiotic and helps prevent bacterial growth while the immune system clears the infection. Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome.
Dec 11, 2022 · Fusidic acid cream and sodium fusidate ointment are antibacterial preparations which usually clear skin infection quickly, particularly where the infection only covers a small area.
About fusidic acid - NHS
Fusidic acid is an antibiotic. It works by stopping bacteria from growing. It's used to treat bacterial infections, such as skin infections including cellulitis and impetigo, and eye infections including conjunctivitis (red, itchy eyes). Fusidic acid is only available on prescription. It comes as a cream, ointment, or eye drops.
How and when to use fusidic acid - NHS
Fusidic acid eye drops come as a gel in a tube. As the gel touches your eye it becomes runnier. Dosage for fusidic acid eye drops. You'll usually put 1 drop into your eye twice a day, once in the morning and once in the evening. How to use fusidic acid eye drops. Take the cap off the tube when you're ready to use the medicine.
Fusidic Acid | C31H48O6 | CID 3000226 - PubChem
Fusidic acid is a steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum. It has a role as a protein synthesis inhibitor, an EC 2.7.1.33 (pantothenate kinase) inhibitor and an Escherichia coli metabolite.
Fusidic acid | Drugs | BNF | NICE
View fusidic acid information, including dose, uses, side-effects, pregnancy, breast feeding, monitoring requirements, directions for administration and drug action.
