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      Guanine nucleotide-binding protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene.
      Its main product is the heterotrimeric G-protein alpha subunit Golf-α, a member of the Gs alpha subunit family that is a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways in the olfactory system and the striatum in the brain. It also mediated D1 receptor signalling in the striatum and is hence involved in motor control.


      See also


      Second messenger system
      G protein-coupled receptor
      Heterotrimeric G protein
      Adenylyl cyclase
      Protein kinase A
      Olfactory receptors


      References




      Further reading

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    GNAL - Wikipedia

    Guanine nucleotide-binding protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene.

    Art Education | Greater Norristown Art League | East Norriton

    Greater Norristown Art League (GNAL) is an art education non profit in East Norriton, Pa. We hold adult classes, children's classes, art shows and summer art camp.

    GNAL Gene - GeneCards | GNAL Protein | GNAL Antibody

    Dec 25, 2024 · GNAL (G Protein Subunit Alpha L) is a Protein Coding gene. Diseases associated with GNAL include Dystonia 25 and Dystonia . Among its related pathways are GABA B …

    Mutations in GNAL : A Novel Cause of Craniocervical Dystonia

    The GNAL gene encodes the stimulatory α subunit, Gα olf, that links G protein–coupled receptors to downstream effector molecules and functions as a heterotrimer composed of α, β, and γ …

    GNAL G protein subunit alpha L [ (human)] - National Center for ...

    The GNAL dystonia gene is central for striatal responses to dopamine (DA) and is a component of a molecular pathway already implicated in DOPA-responsive dystonia (DRD). GNAL mutations …

    Mutations in GNAL : A Novel Cause of Craniocervical Dystonia

    Mutations in the GNAL gene have recently been shown to cause primary torsion dystonia. The GNAL-encoded protein (Gα olf) is important for dopamine D 1 receptor function and odorant …

    GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA …

    Feb 12, 2013 · Vuoristo, J. T., Berrettini, W. H., Overhauser, J., Prockop, D. J., Ferraro, T. N., Ala-Kokko, L. Sequence and genomic organization of the human G-protein Golf-alpha gene …

    DYT-GNAL - GeneReviews® - NCBI Bookshelf

    Jan 3, 2019 · DYT-GNAL caused by a heterozygous GNAL pathogenic variant has been reported in more than 60 individuals to date. It is characterized by adult-onset isolated dystonia (i.e., no …

    Mutations in GNAL cause primary torsion dystonia - Nature

    Dec 9, 2012 · Laurie Ozelius and colleagues identify mutations in GNAL in families with primary torsion dystonia, a movement disorder characterized by repetitive twisting muscle contractions …

    Gnal guanine nucleotide binding protein, alpha stimulating, …

    Feb 8, 2025 · Gnal guanine nucleotide binding protein, alpha stimulating, olfactory type [ (house mouse)] Gene ID: 14680 , updated on 8-Feb-2025 Summary