hyoscine butylbromide

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      Hyoscine butylbromide, also known as scopolamine butylbromide and sold under the brandname Buscopan among others, is an anticholinergic medication used to treat abdominal pain, esophageal spasms, bladder spasms, biliary colic, and renal colic. It is also used to improve excessive respiratory secretions at the end of life. Hyoscine butylbromide can be taken by mouth, injection into a muscle, or into a vein.
      Side effects may include sleepiness, vision changes, dry mouth, rapid heart rate, triggering of glaucoma, and severe allergies. Sleepiness is uncommon. It is unclear if it is safe in pregnancy. It appears safe in breastfeeding. Greater care is recommended in those with heart problems. It is an anticholinergic agent, which does not have much effect on the brain.
      Hyoscine butylbromide was patented in 1950, and approved for medical use in 1951. It is on the World Health Organization's List of Essential Medicines. It is not available for human use in the United States, and a similar compound methscopolamine may be used instead. It is manufactured from hyoscine - also known as scopolamine - which occurs naturally in a variety of plants in the nightshade family, Solanaceae, including deadly nightshade (Atropa belladonna).
      It is available in the United States only for the medical treatment of horses.


      Medical uses



      Hyoscine butylbromide is effective in treating crampy abdominal pain.
      Hyoscine butylbromide is effective in reducing the duration of the first stage of labour, and it is not associated with any obvious adverse outcomes in mother or neonate.
      It is also used during abdominal, pelvic MRI, virtual colonoscopy, and double barium contrasted studies to improve the quality of pictures. Hyoscine butylbromide can reduce the peristaltic movement of the intestines and mucosal foldings, thus reducing the movement artifact of the images.


      Side effects


      Since little of the medication crosses the blood-brain barrier, this drug has less effect on the brain and therefore causes a reduced occurrence of the centrally-mediated effects (such as delusions, somnolence and inhibition of motor functions) which reduce the usefulness of some other anticholinergic drugs.
      Hyoscine butylbromide is still capable of affecting the chemoreceptor trigger zone, due to the lack of a well-developed blood-brain barrier in the medulla oblongata, which increases the antiemetic effect it produces via local action on the smooth muscle of the gastrointestinal tract.
      Other side effects include accommodation reflex disturbances, tachycardia, dry mouth, nausea; urinary retention, reduced blood pressure; dyshidrosis; Other symptoms are dizziness, flushing and immune system disorders (anaphylactic shock, potentially fatal); anaphylactic reactions; dyspnoea; skin reactions and other hypersensitivity reactions. Cautions should be taken for those with untreated glaucoma, heart failure, benign prostatic hyperplasia with urinary retention as hyoscine may exacerbate these conditions.


      Pharmacology


      Hyoscine butylbromide reduces smooth muscle contraction and the production of respiratory secretions. These are normally stimulated by the parasympathetic nervous system, via the neurotransmitter acetylcholine. As an antimuscarinic, hyoscine butylbromide binds to muscarinic acetylcholine receptors, blocking their effect.
      It is a quaternary ammonium compound and a semisynthetic derivative of hyoscine hydrobromide (scopolamine). The attachment of the butyl-bromide moiety effectively prevents the movement of this drug across the blood–brain barrier, effectively minimising undesirable central nervous system side effects associated with scopolamine/hyoscine.


      Abuse


      Hyoscine butylbromide is not centrally active and has a low incidence of abuse. In 2015, it was reported that prisoners at Wandsworth Prison and other UK prisons were smoking prescribed hyoscine butylbromide, releasing the potent hallucinogen scopolamine. There have also been reports of abuse in Mashhad Central Prison in Iran.


      References

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    Hyoscine butylbromide - Wikipedia

    Hyoscine butylbromide, also known as scopolamine butylbromide [4] and sold under the brandname Buscopan among others, [5] is an anticholinergic medication used to treat …

    Hyoscine butylbromide tablets - Buscopan. (Side effects, dosage) …

    Oct 15, 2023 · Hyoscine butylbromide is an antispasmodic medicine which is taken to relieve cramps in the stomach, intestines or bladder. In particular, it helps to ease bloating and the …

    Buscopan: medicine to treat stomach cramps and IBS - NHS

    Buscopan relieves painful stomach cramps, including those linked with irritable bowel syndrome (IBS). It can also help bladder cramps and period pain. Buscopan contains the active …

    Buscopan - Uses, Side Effects, Interactions - MedBroadcast.com

    Hyoscine reduces spasms by relaxing smooth muscles within the stomach, intestines, bladder and urethra. The injection form is used to relieve these same types of muscles spasms that …

    Hyoscine Butylbromide: Uses, Dosage, Side Effects, and More

    Hyoscine Butylbromide is an oral medication designed to block the action of endothelin, a natural substance in the body that narrows blood vessels. By inhibiting endothelin, Hyoscine …

    Hyoscine Butylbromide - Uses, Dosage, Side Effects, Price

    Oct 8, 2021 · Hyoscine Butylbromide is an antispasmodic (a medicine used to relieve spasms) is used to relieve cramps (sharp pain) associated with the gastrointestinal tract (stomach and …

    Hyoscine butylbromide: a review of its use in the treatment of

    Hyoscine butylbromide (scopolamine butylbromide) [Buscopan/Buscapina] is an antispasmodic drug indicated for the treatment of abdominal pain associated with cramps induced by …

    Buscopan® 10mg Tablets / Hyoscine-N-butylbromide 10mg …

    Buscopan Tablets contain a medicine called “hyoscine butylbromide”. This belongs to a group of medicines called “antispasmodics”. Bladder and the tubes that lead to the outside of your body …

    Hyoscine butylbromide | Drugs | BNF | NICE

    View hyoscine butylbromide information, including dose, uses, side-effects, pregnancy, breast feeding, contra-indications, important safety information and directions for administration.

    Hyoscine butylbromide: View Uses, Side Effects and Medicines

    Jul 25, 2022 · Hyoscine butylbromide is an anticholinergic medication. It works by relaxing the muscles in the stomach and gut (intestine). It stops sudden muscle contractions (spasms), …