lidocaine prilocaine

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    Lidocaine/prilocaine is a eutectic mixture of equal quantities (by weight) of lidocaine and prilocaine. A 5% emulsion preparation, containing 2.5% each of lidocaine/prilocaine, is marketed by APP Pharmaceuticals under the trade name EMLA (an abbreviation for Eutectic Mixture of Local Anesthetics). As a spray, it is marketed under the name Tempe (topical eutectic-like mixture for premature ejaculation) (PSD502) that can be used by men to help with premature ejaculation. The spray is manufactured by Plethora Solutions and branded as Fortacin in the UK and Recordati in the EU.


    Eutectic mixture


    Separately, lidocaine and prilocaine are solid bases. When mixed in equal quantities by weight, however, they form a eutectic mixture – that is the melting point of the mixture is lower than the melting points of the individual components. The lidocaine/prilocaine eutectic mixture is an oil with a melting point of 18 °C, and can be formulated into preparations without the use of a non-aqueous solvent. This allows higher concentrations of anaesthetic to be formulated into the preparation and maintained during application.


    Clinical use




    = Indications

    =
    The lidocaine/prilocaine combination is indicated for dermal anaesthesia. Specifically it is applied to prevent pain associated with intravenous catheter insertion, blood sampling, superficial surgical procedures, and topical anaesthesia of leg ulcers for cleansing or debridement. Also, it can be used to numb the skin before tattooing as well as electrolysis and laser hair removal. It is also sometimes used in advance of injected local anaesthetics for minor surgery and biopsies.
    A topical spray consisting of an aerosol formulation of lidocaine and prilocaine was evaluated under the name PSD502 for use in treating premature ejaculation. The spray is applied on the penile skin prior to intercourse. While this formulation was not approved by the FDA, a similar product, Promescent, is available over-the-counter in the U.S.


    = Dosage forms

    =
    Lidocaine/prilocaine eutectic mixture is marketed as a 5% oil-in-water emulsion incorporated in a cream base (EMLA cream) or a cellulose disk (EMLA patch). The cream is applied under an occlusive dressing, while the patch incorporates an occlusive dressing to facilitate absorption of lidocaine and prilocaine into the area where anaesthesia is required. Local dermal anaesthesia is achieved after approximately 60 minutes, whereupon the occlusive dressing (or patch) is removed. The duration of anaesthesia is approximately two hours following removal of the occlusive dressing.
    E. Fougera & Co., makers of the generic cream widely used in the United States as Lidocaine and Prilocaine Cream, 2.5%/2.5%, recommends different timing for application of the cream as well as length of anesthesia. They state the cream must be applied at least one hour before the start of a routine procedure and for two hours before the start of a painful procedure. Additionally, they state that the duration of effective skin anesthesia will be at least one hour after removal of the occlusive dressing.


    = Circumcision

    =
    Lidocaine/prilocaine eutectic mixture has been used during circumcision in newborn boys and has been considered efficacious and safe to lessen pain from circumcision.
    The European Medicines Agency concludes in its latest (2014) statement on Emla:
    "Safety and efficacy for the use of EMLA on genital skin and genital mucosa have not been established in children younger than 12 years. Available paediatric data do not demonstrate adequate efficacy for circumcision."
    The Patient Information Leaflet of EMLA in the UK states: "EMLA Cream should not be applied to the genital skin (e.g. penis) and genital mucosa (e.g. in the vagina) of children (below 12 years of age) owing to insufficient data on absorption of active
    substances."


    Tempe


    The spray is a combination of local anaesthetics lidocaine and prilocaine in a metered-dose aerosol that is sprayed directly on the penis to numb sensations. It was developed by the same group that invented the erectile dysfunction drug sildenafil. The drug was approved in Europe and was released in the UK market in November 2016 and within the EU will be marketed by, early in 2017 In the United States, the Food and Drug Administration (FDA) is expected to approve the drug in 2018.


    Compendial status


    United States Pharmacopeia 31


    See also


    Dosage form
    Eutectic point
    Lidocaine
    Prilocaine


    References




    External links


    "Lidocaine mixture with Prilocaine". Drug Information Portal. U.S. National Library of Medicine.

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Lidocaine and prilocaine topical Uses, Side Effects & Warnings - Drugs.com

Lidocaine and prilocaine topical (for the skin) is a combination medicine used to numb the skin or surfaces of the penis or vagina. lidocaine and prilocaine topical is used to prepare you for minor surgery or medical procedures on these areas.

Lidocaine/prilocaine: Uses, Side Effects, Dosage & Reviews - GoodRx

Sep 30, 2021 · Lidocaine/prilocaine is a combination medication containing lidocaine and prilocaine. It works well to treat and prevent pain on your skin or genital area, and it's typically used to numb the skin before procedures or injections.

Lidocaine/Prilocaine (Emla) - Uses, Side Effects, and More

Overview: Lidocaine/prilocaine is primarily used for pain relief or to numb part of your body before a minor surgical procedure. It works by temporarily blocking nerve signals that cause you to...

Lidocaine and prilocaine (topical application route) - Mayo Clinic

Lidocaine and prilocaine topical cream is used on the skin or in the genital area to cause numbness or loss of feeling before certain medical procedures. It is also used to prevent pain caused by an injection, the drawing of blood from a vein, …

Lidocaine and Prilocaine Cream Information - Drugs.com

Lidocaine and Prilocaine Cream. Generic name: Lidocaine and Prilocaine Cream [ LYE-doe-kane-& PRIL-oh-kane ] Brand name: EMLA Drug class: Topical anesthetics. Medically reviewed by Drugs.com. Last updated on Apr 28, 2024. Uses; Before taking; Warnings; Dosage; Side effects; Overdose; Uses of Lidocaine and Prilocaine Cream:

Lidocaine and Prilocaine: Package Insert / Prescribing Info - Drugs.com

Feb 10, 2025 · Lidocaine and Prilocaine package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology.

Lidocaine vs. Prilocaine - What's the Difference? - This vs. That

Lidocaine and Prilocaine are both local anesthetics commonly used in medical and dental procedures to numb the skin or mucous membranes. While Lidocaine is a fast-acting anesthetic that provides quick pain relief, Prilocaine has a slower onset of action but offers a …

Lidocaine/prilocaine - Wikipedia

Lidocaine/prilocaine is a eutectic mixture of equal quantities (by weight) of lidocaine and prilocaine. A 5% emulsion preparation, containing 2.5% each of lidocaine/prilocaine, is marketed by APP Pharmaceuticals under the trade name EMLA (an abbreviation for Eutectic Mixture of Local Anesthetics ). [ 5 ]

Lidocaine-Prilocaine-Lidocaine HCl Topical: Uses, Side Effects ... - WebMD

It is used on normal, unbroken skin or on the outer genital area to prevent pain before certain procedures such as inserting a needle, skin grafts, or skin laser surgery. It...

Lidocaine and Prilocaine - Medicine.com

Feb 9, 2020 · Includes Lidocaine and Prilocaine indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more.