1988 UEFA European Championship final highlights - YouTube
5 Feb 2016 ... See Marco van Basten's sensational volley and Ruud Gullit's headed opener as the Netherlands overcame the Soviet Union to claim European ...
EURO 1988 final highlights: Netherlands 2-0 USSR - UEFA.com
See Marco van Basten's sensational volley and Ruud Gullit's headed opener as the Netherlands overcame the Soviet Union to claim European glory in Munich.
V8 Supercar Series 2002 - Driver Database
statistics ; 1. Mark Skaife ; 2. Greg Murphy ; 3. Marcos Ambrose ; 4. Jason Bright ; 5. Todd Kelly.
2003 Supercars Images
V8 Supercars Championship Series, Rd3, Eastern Creek Raceway, Sydney, Australia, 4 May 2003. ... Marcos Ambrose (AUS) Pirtek Racing Ford Falcon lead from start to ...
66 Supercars Images : Eastern Creek (2003)
Marcos Ambrose (AUS) Pirtek Racing Ford Falcon lead from start to finish to win the race. V8 Supercars Championship Series, Rd3, Eastern Creek Raceway, Sydney, ...
- Source: Marco
- Source: MARCO
- Marco Polo
- Marco van Basten
- Marco Motta
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- Marco Asensio
- Marco Materazzi
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- Marco Kartodikromo
- Perjalanan Marco Polo
- Marco Polo (seri televisi)
- Marco
- MARCO
- Mars Cube One
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- MARCOS
- Marco Polo (disambiguation)
Burning Betrayal (2023)
marco
Artikel: Marco GudangMovies21 Rebahinxxi
Marco may refer to:
People
Marco (given name), people with the given name Marco
Marco (actor) (born 1977), South Korean model and actor
Georg Marco (1863–1923), Romanian chess player of German origin
Jindřich Marco (1921–2000), Czechoslovak photographer and numismatist
Joseph Marco (born 1988), Filipino actor
María del Pilar Sinués de Marco (1835–1893), Spanish writer
Tomás Marco (born 1942), Spanish composer and writer on music
Places
Marco, Ceará, Brazil, a municipality
Marco, New Zealand, a locality in the Taranaki Region
Marco, Indiana, United States, an unincorporated town
Marco, Missouri, United States, an unincorporated community
Marco Island, Florida, United States, a city and an island
Science and technology
Mars Cube One (MarCO), a pair of small satellites which fly by Mars in 2018
MARCO, a macrophage receptor protein that in humans is encoded by the MARCO gene
Mid-Atlantic Regional Council on the Ocean (MARCO)
Marco, the official window manager of MATE
Maia and Marco, one of an artificial intelligence sportscaster pair
Arts and entertainment
Marco: 3000 Leagues in Search of Mother, a 1976 Japanese anime series, directed by Isao Takahata
Marco (1973 film), an American adventure film directed by Seymour Robbie
Marco, the Invented Truth, a 2024 Spanish biographical drama film
Marco (comics), a fictional character in the DC Comics universe
Marco Pagot, the main protagonist in Porco Rosso
Marco (Animorphs), one of the six main characters in the book series Animorphs
Marco, a character in the animated family comedy film Chibi Maruko-chan: A Boy From Italy
"Marco" (Better Call Saul), an episode of Better Call Saul
Marco (Marco Borsato album), 1994
Marco (Marco Antonio Solís album), 1997
Museo de Arte Contemporáneo de Monterrey (MARCO), the Museum of Contemporary Art in Monterrey, Mexico
Marco (2024 film), an Indian Malayalam language film directed by Haneef Adeni
Other uses
F.C. Marco, a former football club from Marco de Canaveses, Portugal
Hurricane Marco
Tropical Storm Marco
See also
Macro (disambiguation)
Marko (disambiguation)
Narco (disambiguation)
Artikel: MARCO GudangMovies21 Rebahinxxi
Macrophage receptor with collagenous structure (MARCO) is a protein that in humans is encoded by the MARCO gene. MARCO is a class A scavenger receptor that is found on particular subsets of macrophages. Scavenger receptors are pattern recognition receptors (PRRs) found most commonly on immune cells. Their defining feature is that they bind to polyanions and modified forms of a type of cholesterol called low-density lipoprotein (LDL). MARCO is able to bind and phagocytose these ligands and pathogen-associated molecular patterns (PAMPs), leading to the clearance of pathogens and cell signaling events that lead to inflammation. As part of the innate immune system, MARCO clears, or scavenges, pathogens, which leads to inflammatory responses. The scavenger receptor cysteine-rich (SRCR) domain at the end of the extracellular side of MARCO binds ligands to activate the subsequent immune responses. MARCO expression on macrophages has been associated with tumor development and also with Alzheimer's disease, via decreased responses of cells when ligands bind to MARCO.
Structure
MARCO is a transmembrane protein that has 5 domains (see figure). The domain within the cell is called the cytoplasmic domain, as well as a transmembrane domain. The extracellular regions of MARCO include a spacer domain, a collagenous domain, and the SRCR domain. The SRCR domain is required for MARCO binding to ligands, via 2 highly conserved arginine residues, termed the RxR motif.
Other members of the class A scavenger receptors tend to have alpha helical coiled coil domains, but MARCO does not. The C-terminal SRCR domain of MARCO affects the ability of the receptor to bind and take up ligand, activate inflammatory signaling, and adhere to surfaces.
Cell expression
MARCO is expressed on a subset of tissue-resident macrophages in normal tissues, as well as circulating monocytes, dendritic cells, and B cells. MARCO is typically present on the macrophages in the marginal zone of the spleen and the medullary lymph nodes, but it is also found in the liver. Dendritic cells increase expression of MARCO when exposed to certain pathogens, resulting in alterations to the cytoskeleton of dendritic cells and increased phagocytosis.
MARCO is highly expressed by macrophages and monocytes in the tumor microenvironment (TME), including tumor-associated macrophages (TAMs) and monocytic myeloid-derived suppressor cells (mMDSCs). Expression of MARCO correlated (FDR < 0.01 and R > 0.2126212) with expression of genes associated with immunosuppressive TAMs, such as CD68, CD163, MSR1, IL4R, CHIA, TGFB1, IL10, and IL37, whereas no correlation was observed with expression of inducible nitric oxide synthase (NOS2), which is expressed by macrophages with an anti-tumor phenotype.
Functions
= Phagocytosis
=The primary function of scavenger receptors is to regulate phagocytosis of pathogens, but they also participate in cell–cell recognition and initiation of inflammatory responses. MARCO, being a PRR, is able to bind to a wide variety of bacteria, making it an important receptor for activating an immune response against bacteria. Soluble LPS and entire bacteria can each bind bind to MARCO, as well as acetylated LDL (AcLDL), oxidized LDL (OxLDL), B cells in the marginal zone of the spleen, and apoptotic cells. MARCO is therefore able to recognize and phagocytose pathogens and apoptotic cells, and operates independently of opsonization.
= Regulation of Inflammation
=MARCO does not directly cause an inflammatory response, but it can interact with PAMPs to promote inflammation. One way MARCO does this is by tethering a pathogen to other receptors on the cell, including PRRs such as TLR2, which then lead to the activation of the transcription factor NF-κB, which regulates expression of genes that encode cytokines. Through phagocytosis, MARCO also brings pathogens into the cell, which are processed by intracellular compartments that contain other signaling receptors such as TLR3, NOD2, and NALP3. However, lung cancer cells polarize macrophages to express MARCO and acquire an immune-suppressive phenotype, through the release of IL37. MARCO-expressing TAMs blocked activation of cytotoxic T cells and NK cells, inhibiting their proliferation, cytokine production, and tumor-cell killing capacity. Furthermore, MARCO+ macrophages increased proliferation of T-regulatory (Treg) cells and production of IL10, and diminished activity of CD8+ T cells. Blocking MARCO or knocking out IL37 in lung cancer cell lines repolarized TAMs, resulting in recovered cytolytic activity and anti-tumor effects of natural killer (NK) cells and T cells, as well as reduced Treg-cell activities.
Association with diseases
= Alzheimer's disease
=The activity of MARCO on microglia, the macrophages of the brain, is believed to be altered in development of Alzheimer's disease. One primary characteristic of Alzheimer's disease is the presence of numerous senile plaques in the brain that contain amyloid beta peptides (Aβ). Initially, the microglia clear the Aβ, which binds to receptors such as MARCO. During development of Alzheimer's disease, however, the ability of microglia to clear Aβ is decreased, resulting in Aβ accumulation, which is neurotoxic. MARCO also interacts with formyl peptide receptor 2 (FPR2) to form a complex that causes the microglia to release inflammatory cytokines, which can also cause damage to neurons.
= Cancer
=Antibodies against MARCO have been shown to slow growth and metastasis in syngeneic mouse tumor models, by reprogramming immunosuppressive (M2)-like TAMs into inflammatory (M1)-like macrophages. This switch involves changes to the metabolic program of the macrophages and activation of NK cells. In addition, targeting MARCO on human macrophages repolarizes TAMs and restores the cytotoxic, anti-tumor capacities of NK and T cells. These findings indicate that strategies that target MARCO-expressing TAMs to remodel the immune-suppressive tumor microenvironment might be developed for cancer therapy.
In non-small-cell lung cancer (NSCLC) tissues, researchers found an association between expression of MARCO mRNA and genes that regulate immune response pathways, including immunosuppressive TAMs, T-cell infiltration, and immune checkpoint molecules. Higher infiltration of tumor tissues by macrophages was seen in tumors expressing PD-L1; macrophages within tumor cell nests co-expressed MARCO and PD-L1. MARCO is therefore a target of immune therapeutic strategies to inhibit TAMs in NSCLC, possibly in combination with immune checkpoint inhibitors.
In patients with renal cell carcinoma or colorectal cancer, those with tumors that expressed low levels of MARCO had longer survival times than patients whose tumors expressed high levels of MARCO. Additionally, high MARCO levels are observed in patients with melanoma that is refractory to checkpoint inhibitor therapy, and patients with solid tumors refractory to chemotherapy.
References
Further reading
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Marcos.com
MARCO'S. REAL BIG PIZZA DEAL. 30 % OFF. ALL MENU-PRICE PIZZAS. USE CODE: BIGDEAL. Order Now. Terms and conditions apply. See below any fresh baked sub $ 8. 99. …
Menu - Marcos.com
Build your own pizza or choose from one of Marco's specialty pizzas. Dough made fresh and quality ingredients make for pizza made the primo way. Add cheezybread, wings & more!
Marco's Pizza Online Ordering
31 Jul 2021 · Marco's Pizza Online Ordering is designed for ease-of-use. It’s quick and easy to create an order, purchase, and schedule for delivery. Create an order now!
About Marcos | Marcos.com
Serving authentic Italian quality pizza since 1978. With about 900 stores across 35 states, Marco's Pizza is one of the fastest growing pizza companies in America.
Primo Deals - Marcos.com
MARCO'S. REAL BIG PIZZA DEAL. 30 % OFF. ALL MENU-PRICE PIZZAS. USE CODE: BIGDEAL. Order Now. Terms and conditions apply. See below any fresh baked sub $ 8. 99. …
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We recommend contacting the Marco’s Pizza location you ordered from for assistance. Where can I find the menu? You can find our menu at https://www.marcos.com/menu/
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Marco’s Pizza Kicks Off 2025: Recapping a Stellar 2024 and …
Development & Innovation Take Center Stage in 2025 as Marco’s Stakes its Claim as One of the Industry Leaders . Marco’s Pizza, one of the nation’s fastest-growing pizza brands, enters …
The Italian Way - Marcos.com
Just when you thought our dough and sauce couldn’t be topped, let us introduce you to our cheese. Actually, make that our cheeses. Because every Marco’s pizza is crafted with a …
Catering - Marcos.com
From corporate events to private parties, Marco’s Pizza ® has something for everyone, every occasion, and every budget. Set the table with delicious pizza, subs, sides, salads, and more …