mcoln1

      MCOLN1 GudangMovies21 Rebahinxxi LK21

      Mucolipin-1 (ML1) also known as TRPML1 (transient receptor potential cation channel, mucolipin subfamily, member 1) is a protein that in humans is encoded by the MCOLN1 gene. It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.
      TRPML1 is a 65 kDa protein associated with mucolipidosis type IV. Its predicted structure includes six transmembrane domains, a transient receptor potential (TRP) cation-channel domain, and an internal channel pore. TRPML1 is believed to channel iron ions across the endosome/lysosome membrane into the cell and so its malfunction causes cellular iron deficiency. It is important in lysosome function and plays a part in processes such as vesicular trafficking, exocytosis and autophagy.


      Ligands


      Agonists
      ML-SA1
      MK6-83


      See also


      transient receptor potential cation channel, mucolipin subfamily, member 2 (MCOLN2)
      transient receptor potential cation channel, mucolipin subfamily, member 3 (MCOLN3)
      mucolipidosis type IV
      TRPML


      References




      External links


      GeneReviews/NIH/NCBI/UW entry on Mucolipidosis IV
      mucolipin-1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

    Kata Kunci Pencarian: mcoln1

    mcoln1mcoln1 genemcoln1 gene mutationmcoln1 gene therapy corrects neurologic dysfunction in the mouse model of mucolipidosis ivmcoln1 omimmcoln1 is a ros sensor in lysosomes that regulates autophagymcoln1 antibodymcoln1 autophagymcoln1 genereviewsmcoln1 function