- Source: N-Desmethyltamoxifen
- N-Desmethyltamoxifen
- N,N-Didesmethyltamoxifen
- Tamoxifen
- Endoxifen
- Anastrozole
- Selective estrogen receptor modulator
- List of selective estrogen receptor modulators
- List of investigational sex-hormonal agents
- Norendoxifen
Artikel: N-Desmethyltamoxifen GudangMovies21 Rebahinxxi
N-Desmethyltamoxifen (developmental code name ICI-55,548) is a major metabolite of tamoxifen, a selective estrogen receptor modulator (SERM). N-Desmethyltamoxifen is further metabolized into endoxifen (4-hydroxy-N-desmethyltamoxifen), which is thought to be the major active form of tamoxifen in the body. In one study, N-desmethyltamoxifen had an affinity for the estrogen receptor of 2.4% relative to estradiol. For comparison, tamoxifen, endoxifen, and afimoxifene (4-hydroxytamoxifen) had relative binding affinities of 2.8%, 181%, and 181%, respectively.