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      Protein–protein interaction - Wikipedia

      Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect.

      STRING: functional protein association networks

      Upload a complete species proteome to STRING, and we'll generate its interaction network and predict protein functions, including Gene Ontology terms and KEGG pathways. Once uploaded, you can explore and analyze your proteome data through our web interface, access it programmatically via API, or download all predictions in bulk.

      BioGRID | Database of Protein, Chemical, and Genetic Interactions

      BioGRID Is An Online Interaction Respository With Data Compiled Through Comprehensive Curation Efforts. Our Current Index Contains 2,834,410 Raw Protein And Genetic Interactions From Major Model Organism Species.

      Protein–Protein Interactions Essentials: Key Concepts to Building …

      To achieve appropriate understanding of PPIs and to design better ways for analyzing and interpreting them, this educational review presents several essential concepts and definitions intended to facilitate the use of PPI information both by computational and experimental biologists.

      Overview of Protein–Protein Interaction Analysis | Thermo Fisher ...

      Characterizing protein–protein interactions through methods such as co-immunoprecipitation (co-IP), pull-down assays, crosslinking, label transfer, and far–western blot analysis is critical to understand protein function and the biology of the cell. See all …

      Discovery and significance of protein-protein interactions in health ...

      Nov 14, 2024 · The identification of individual protein-protein interactions (PPIs) began more than 40 years ago, using protein affinity chromatography and antibody co-immunoprecipitation.

      Protein-Protein Interaction Detection: Methods and Analysis

      Protein-protein interaction plays key role in predicting the protein function of target protein and drug ability of molecules. The majority of genes and proteins realize resulting phenotype functions as a set of interactions.

      Protein-protein interactions: Methods, databases, and …

      Protein-protein interactions (PPIs) are the physical contacts between two or more proteins and they represent complex biological functions. Nowadays, PPIs have been used to construct PPI networks to study complex pathways for revealing the functions of unknown proteins.

      The protein interactions - The Human Protein Atlas

      Protein-protein interactions are essential for many processes in cellular life, such as cell signaling, gene expression and control and antibody–antigen binding, and they are often blocked or altered in disease.

      Understanding protein interaction dynamics - Nature Methods

      Dec 6, 2024 · Protein–protein interactions (PPIs) form the basis of many biological processes, and the protein interactome reflects the functional state of a biological system at any given moment.