- Pure red cell aplasia
- Aplasia
- Diamond–Blackfan anemia
- Aplastic anemia
- Spin (House)
- Apheresis
- Thymoma with immunodeficiency
- Hematologic disease
- Red blood cell
- Reticulocytopenia
- Pure Red Cell Aplasia (PRCA) - Cleveland Clinic
- Pure red cell aplasia | Blood | American Society of Hematology
- Pure Red Cell Aplasia - StatPearls - NCBI Bookshelf
- Pure red cell aplasia - Wikipedia
- How I manage acquired pure red cell aplasia in adults
- Acquired pure red cell aplasia in adults - UpToDate
- Pure red-cell aplasia | About the Disease | GARD - Genetic and …
- Pure Red Cell Aplasia - PubMed
- Pure Red Cell Aplasia (PRCA) - Aplastic Anemia and MDS …
- Pure red cell aplasia - PubMed
pure red cell aplasia
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Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of aplastic anemia affecting the precursors to red blood cells but usually not to white blood cells. In PRCA, the bone marrow ceases to produce red blood cells. There are multiple etiologies that can cause PRCA. The condition has been first described by Paul Kaznelson in 1922.
Signs and symptoms
Signs and symptoms may include:
Pale appearance
Rapid heart rate
Fatigue
Causes
Causes of PRCA include:
Diagnosis
Treatment
PRCA is considered an autoimmune disease as it will respond to immunosuppressant treatment such as cyclosporin in many patients, though this approach is not without risk.
It has also been shown to respond to treatments with rituximab and tacrolimus.
For cases related to B19 parvovirus, administration of commercial immunoglobulin can treat or cure parvovirus by replacing neutralizing antibodies.
See also
Diamond–Blackfan anemia (genetic red cell aplasia)
Aplastic anemia (aplasia affecting other bone marrow cells as well)
References
External links
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Pure Red Cell Aplasia (PRCA) - Cleveland Clinic
What is pure red cell aplasia (PRCA)? Pure red cell aplasia (PRCA) is a rare blood disorder that happens when your bone marrow doesn’t produce the normal number of red blood cells. When your red blood cell supply drops below normal levels, you have anemia.
Pure red cell aplasia | Blood | American Society of Hematology
Nov 24, 2016 · Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond …
Pure Red Cell Aplasia - StatPearls - NCBI Bookshelf
Feb 24, 2024 · Pure red cell aplasia (PRCA) is a rare disorder that presents with anemia from failure of erythropoiesis. This condition is characterized by normocytic, normochromic anemia with associated reticulocytopenia and absent or infrequent erythroblasts in the bone marrow.
Pure red cell aplasia - Wikipedia
Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of aplastic anemia affecting the precursors to red blood cells but usually not to white blood cells. In PRCA, the bone marrow ceases to produce red blood cells.
How I manage acquired pure red cell aplasia in adults
Apr 15, 2021 · Pure red cell aplasia (PRCA) is a rare bone marrow (BM) disorder characterized by malproductive, reticulocytopenic, normocytic anemia and the disappearance of erythroid precursors. 1 Nosologically, among hematological diseases, PRCA resides within single-lineage cytopenias, sharing clinical features with BM failure syndromes and autoimmune ...
Acquired pure red cell aplasia in adults - UpToDate
Jul 26, 2024 · Acquired pure red cell aplasia (PRCA) is a rare cause of profound anemia characterized by a very low reticulocyte count and the virtual absence of erythroid precursors in the bone marrow. All other cell lineages are present in normal numbers and appear morphologically normal.
Pure red-cell aplasia | About the Disease | GARD - Genetic and …
Pure red cell aplasia (PRCA) is a rare condition that affects the bone marrow. Bone marrow contains stem cells which develop into the red blood cells that carry oxygen through the body, the white blood cells that fight infections, and the platelets that help with blood clotting.
Pure Red Cell Aplasia - PubMed
Feb 24, 2024 · Pure red cell aplasia (PRCA) is a rare disorder that presents with anemia from failure of erythropoiesis. This condition is characterized by normocytic, normochromic anemia with associated reticulocytopenia and absent or infrequent erythroblasts in the bone marrow.
Pure Red Cell Aplasia (PRCA) - Aplastic Anemia and MDS …
What is Pure Red Cell Aplasia or PRCA? There are three types of PRCA: Acquired Pure Red Cell Aplasia: This is a very rare condition and usually affects adults. It is characterized by an absence of red cell precursors (reticulocytes) in the marrow and a low red blood cell count. The amounts of white blood cells and platelet remain normal.
Pure red cell aplasia - PubMed
Nov 24, 2016 · Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond …