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Rh-associated glycoprotein (RHAG) is an ammonia transporter protein that in humans is encoded by the RHAG gene. RHAG has also recently been designated CD241 (cluster of differentiation 241). Mutations in the RHAG gene can cause stomatocytosis.




Function


The Rh blood group antigens (MIM 111700) are associated with human erythrocyte membrane proteins of approximately 30 kD, the so-called Rh30 polypeptides. Heterogeneously glycosylated membrane proteins of 50 and 45 kD, the Rh50 glycoproteins, are coprecipitated with the Rh30 polypeptides on immunoprecipitation with anti-Rh-specific mono- and polyclonal antibodies. The Rh antigens appear to exist as a multisubunit complex of CD47 (MIM 601028), LW (MIM 111250), glycophorin B (MIM 111740), and play a critical role in the Rh50 glycoprotein [supplied by OMIM].




Interactions


RHAG has been shown to interact with ANK1.




See also


Rh deficiency syndrome




References



This article incorporates text from the United States National Library of Medicine, which is in the public domain.




Further reading






External links


RHCE+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
RhAG blood group system in the BGMUT blood group antigen gene mutation database

Kata Kunci Pencarian:

• Akuaporin 1
• Transporter amonium
• RHAG
• Rh blood group system
• RHD (gene)
• Homosexuality
• Red blood cell
• Ammonia transporter
• Pseudo palladium
• Biology and sexual orientation
• GLUT4
• Nucleoside transporter

RHAG

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