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      Robert Brainard Corey (August 19, 1897 – April 23, 1971) was an American biochemist, mostly known for his role in discovery of the α-helix and the β-sheet with Linus Pauling. Also working with Pauling was Herman Branson. Their discoveries were remarkably correct, with even the bond lengths being accurate until about 40 years later. The α-helix and β-sheet are two structures that are now known to form the backbones of many proteins.


      Academic training


      A childhood polio survivor, Corey received his undergraduate degree from the University of Pittsburgh, and his Ph.D. in chemistry from Cornell University (Marsh, p. 52-53).


      The findings of α-helix and β-sheet


      At Caltech, the trio (Pauling, Corey and Branson) published a series of articles in the Proceedings of the National Academy of Sciences.

      The most revolutionary of the articles in PNAS is the one written on February 28, 1951. That date was also Pauling's 50th birthday. It was called "The Structure of Proteins: Two Hydrogen-Bonded Helical Configurations of the Polypeptide Chain". In the paper, one odd thing is that the trio diagrammed the α-helix as a left-handed helix, although it is really a right-handed one. Another odd thing in the paper is that the 3(10) helix is almost never mentioned, although it is very common, while the γ-helix, which was another focus of the paper, is almost never found in nature.


      See also


      CPK coloring
      Corey-Pauling rules


      References




      External links


      The Protein Papers by Christen Brownlee, in PNAS at 100: Classics of the Scientific Literature, special issue of the Proceedings of the National Academy of Sciences
      Robert Brainard Corey by Richard E. Marsh, Biographical Memoirs V.72 (1997) of the National Academy of Sciences
      Key Participants: Robert B. Corey – It's in the Blood! A Documentary History of Linus Pauling, Hemoglobin, and Sickle Cell Anemia; and Key Participants: Robert B. Corey – Linus Pauling and the Race for DNA: A Documentary History
      National Academy of Sciences Biographical Memoir

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