satiety

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      Satiety (/səˈtaɪ.ə.ti/ sə-TYE-ə-tee) is a state or condition of fullness gratified beyond the point of satisfaction, the opposite of hunger. Following satiation (meal termination), satiety is a feeling of fullness lasting until the next meal. When food is present in the GI tract after a meal, satiety signals overrule hunger signals, but satiety slowly fades as hunger increases.
      The satiety center in animals is located in ventromedial nucleus of the hypothalamus.


      Mechanism


      Satiety is signaled through the vagus nerve as well as circulating hormones. During intake of a meal, the stomach must stretch to accommodate this increased volume. This gastric accommodation activates stretch receptors in the proximal (upper) portion of the stomach. These receptors then signal through afferent vagus nerve fibers to the hypothalamus, increasing satiety.


      Signalling factors


      In addition, as the food moves into the duodenum, duodenal cells release multiple substances that affect digestion and satiety. Glucagon-like peptide-1 (GLP-1) is an incretin released by the duodenum that inhibits relaxation of the stomach. This inhibition causes increased stretch of the stomach, increasing activation of proximal gastric stretch receptors. It also slows overall gut motility, increasing the duration of satiety. This effect is used to increase weight loss and treat obesity through GLP-1 agonists. Cholecystokinin (CCK) is gut peptide produced by the duodenum in response to fat and proteins. CCK has the effect of slowing gut motility and increasing satiety as well as activating release of pancreatic digestive enzymes and bile from the gallbladder.


      See also


      Ghrelin
      Satiety value
      Prader–Willi syndrome


      References

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    Satiety Definition & Meaning - Merriam-Webster

    The meaning of SATIETY is the quality or state of being fed or gratified to or beyond capacity : surfeit, fullness. How to use satiety in a sentence. Is This History of satiety Enough?

    Satiety - Wikipedia

    Satiety (/səˈtaɪ.ə.ti/ sə-TYE-ə-tee) is a state or condition of fullness gratified beyond the point of satisfaction, the opposite of hunger. Following satiation (meal termination), satiety is a feeling of fullness lasting until the next meal. [1]

    SATIETY | English meaning - Cambridge Dictionary

    SATIETY definition: 1. the state of being completely satisfied, especially with food or pleasure, so that you could not…. Learn more.

    Early Satiety: Causes, Treatment & Long-Term Complications

    Dec 3, 2024 · Early satiety can make it hard to get the nutrients your body needs, leading to problems like fatigue, weight loss and even malnutrition. An underlying medical condition is usually the cause of the symptom, and only a healthcare provider can help you figure it out.

    SATIETY | definition in the Cambridge English Dictionary

    SATIETY meaning: 1. the state of being completely satisfied, especially with food or pleasure, so that you could not…. Learn more.

    Satiety - definition of satiety by The Free Dictionary

    Define satiety. satiety synonyms, satiety pronunciation, satiety translation, English dictionary definition of satiety. n. The condition of being full or gratified beyond the point of satisfaction; surfeit.

    Satiety | Appetite Control, Hunger Signals & Eating Behavior ...

    Satiety, desire to limit further food intake, as after completing a satisfying meal. The hypothalamus, part of the central nervous system, regulates the amount of food desired. Eating is thought to increase the body temperature, and as the …