- Terpene synthase N terminal domain
- Terpene
- Terpene synthase C terminal domain
- Terpene synthase
- Limonene
- Capsaicin
- Squalene
- Carotenoid
- Sesquiterpene
- Monoterpene
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In molecular biology, this protein domain belongs to the terpene synthase family (TPS). Its role is to synthesize terpenes, which are part of primary metabolism, such as sterols and
carotene, and also part of the secondary metabolism. This entry will focus on the N terminal domain of the TPS protein.
Function
Terpenes synthases have a role in producing important molecules in metabolism, these molecules are part of a large group called terpenoids. In particular, the N terminal domain has feature of the copalyl diphosphate synthase (CPS) active site.
Structure
The N-terminal domain forms an alpha-barrel similar to that of the sesquiterpene cyclase epiaristolochene synthase.
Conservation
Sequences containing this protein domain belong to the terpene synthase family. It has been suggested that this gene family be designated tps (for terpene synthase). Sequence comparisons reveal similarities between the monoterpene (C10) synthases, sesquiterpene (C15) synthases and the diterpene (C20) synthases. It has been split into six subgroups on the basis of phylogeny, called Tpsa-Tpsf .
Tpsa includes vetispiridiene synthase.
Tpsb includes (-)-limonene synthase.
Tpsc includes copalyl diphosphate synthase (kaurene synthase A).
Tpsd includes taxadiene synthase, pinene synthase, and myrcene synthase.
Tpse includes ent-kaurene synthase B.
Tpsf includes S-linalool synthase. In the fungus Phaeosphaeria sp. (strain L487) the synthesis of ent-kaurene from geranylgeranyl dophosphate is promoted by a single bifunctional protein.
See also
Terpene synthase C terminal domain
References
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Terpene synthase N terminal domain - Alchetron, the free social ...
Evolution of the coniferous terpene synthase (TPS) family and P450 ...
Comparative structural analysis of multi-domain terpene synthase ...
Comparative structural analysis of multi-domain terpene synthase ...
Representation of class I and class II domain within terpene synthase ...
Terpene Pathway
Sequence similarity network of terpene synthase-like 2 subgroup (A ...
New approach to terpene syntheses
Terpene synthases in disguise: enzymology, structure, and opportunities ...
Analysis of terpene biosynthetic pathway genes. (A) Terpene synthases ...
Terpenes produced by characterised terpene synthases. | Download ...
| Pathway of terpene synthesis. | Download Scientific Diagram