thienopyridine

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      Thienopyridines are a class of selective, irreversible ADP receptor/P2Y12 inhibitors used for their anti-platelet activity. They have a significant role in the management of cardiovascular disease.


      Clinical Uses


      They are used in the management of peripheral artery disease, as well as the prevention of coronary stent thrombosis and strokes.


      Examples


      Drugs in this class include:
      clopidogrel (Plavix), prasugrel (Effient), and ticlopidine (Ticlid).
      Tinoridine was actually a predecessor to this work.


      Alternatives


      Ticagrelor (Brilinta) is often listed with thienopyridine inhibitors and has similar indications for use but is not a thienopyridine. It is a cyclo-pentyltriazolo-pyrimidine that is distinct from the mechanism of the thienopyridines in that it reversibly (rather than irreversibly) inhibits the P2Y12 receptor.


      References

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    Thienopyridine - Wikipedia

    Thienopyridines are a class of selective, irreversible [1] ADP receptor / P2Y12 inhibitors used for their anti- platelet activity. They have a significant role in the management of cardiovascular …

    Thienopyridines or Aspirin to Prevent Stroke and Other Serious …

    Jul 1, 2000 · The thienopyridine derivatives, ticlopidine and clopidogrel, are antiplatelet drugs that act through a mechanism different from that of aspirin, by inhibiting the binding of ADP to its …

    Thienopyridine - an overview | ScienceDirect Topics

    Thienopyridines are prodrugs that are biotransformed into molecules that bind irreversibly to the P2Y12 receptor. Three thienopyridines are available: ticlopidine, clopidogrel, and prasugrel. …

    The thienopyridines - PubMed

    The development of the thienopyridines, a class of antiplatelet drugs that reduce adenosine diphosphate- (ADP) mediated platelet activation, has significantly improved clinical outcomes …

    Thienopyridine derivatives versus aspirin for preventing stroke …

    Compared with aspirin, thienopyridines significantly reduced gastrointestinal adverse effects. However, thienopyridines increased the odds of skin rash and diarrhoea, ticlopidine more than …

    Thienopyridine - an overview | ScienceDirect Topics

    The thienopyridines are a class of drugs designed to interfere with ADP-induced platelet aggregation through irreversible binding to the platelet P2Y12 receptor. Thienopyridines …

    Bedside Evaluation of Thienopyridine Antiplatelet Therapy

    May 19, 2009 · Dual antiplatelet therapy with aspirin and a thienopyridine is a cornerstone of treatment for patients with coronary artery disease.

    Thienopyridine - an overview | ScienceDirect Topics

    Thienopyridines are antiplatelet drugs that work by irreversibly inhibiting the binding of ADP on its platelet receptor, preventing the activation of the glycoprotein IIb/IIIa receptor and subsequent …

    Thienopyridine | definition of thienopyridine by ... - Medical …

    Looking for online definition of thienopyridine in the Medical Dictionary? thienopyridine explanation free. What is thienopyridine? Meaning of thienopyridine medical term.

    ACCF/ACG/AHA 2010 Expert Consensus Document on the …

    Nov 8, 2010 · The potential benefits of antiplatelet therapy for atherosclerotic cardiovascular (CV) disease have been amply demonstrated over the past 2 decades, especially with regard to the …