- Sistem imun
- Diabetes melitus
- HIV
- Asam mefenamat
- Atorvastatin
- Lemak
- Sitokin
- Hati
- Metaloproteinase matriks
- Fruitarianisme
- Type 2 inflammation
- Asthma phenotyping and endotyping
- Inflammation
- Asthma-COPD overlap
- Corticosteroid
- Sputum
- Asthma
- Inulin
- Atopic dermatitis
- Aspirin-exacerbated respiratory disease
- Type 2 inflammation - Wikipedia
- Understanding Type 2 Inflammation | For Healthcare Professionals
- Type 2 Inflammation: Conditions, Symptoms, and More - Healthline
- Type 2 chronic inflammatory diseases: targets, therapies and …
- Type 2 Inflammation | AAFA.org
- Chronic Inflammation: Associated Conditions and Symptoms
- Type 2 immunity‐driven diseases: Towards a multidisciplinary …
- Type 2 Inflammatory Disease - American College of Allergy …
- What is Type 2 Inflammation? - Allergy & Asthma Network
- Understanding Type 2 Inflammation - Allergy & Asthma Network
type 2 inflammation
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Type 2 inflammation is a pattern of immune response. Its physiological function is to defend the body against helminths, but a dysregulation of the type 2 inflammatory response has been implicated in the pathophysiology of several diseases.
Molecular biology
IL-25, IL-33, and TSLP are alarmins released from damaged epithelial cells. These cytokines mediate the activation of type 2 T helper cells (Th2 cells), type 2 innate lymphoid cells (ILC2 cells), and dendritic cells. Th2 cells and ILC2 cells secrete IL-4, IL-5 and IL-13.
IL-4 further drives CD4+ T cell differentiation towards the Th2 subtype and induces isotype switching to IgE in B cells. IL-4 and IL-13 stimulate trafficking of eosinophils to the site of inflammation, while IL-5 promotes both eosinophil trafficking and production.
Dysregulation in human disease
Type 2 inflammation has been implicated in several chronic diseases:
Asthma
Atopic dermatitis
Chronic sinusitis with nasal polyps
Eosinophilic esophagitis
Bullous pemphigoid
Persons with one type 2 inflammatory disease are more likely to have other type 2 inflammatory diseases.
Pharmacological targets
Several medicines have been developed that target mediators of type 2 inflammation:
IL-4-specific blockers:
Altrakincept
Pascolizumab
IL-5-specific blockers:
Benralizumab
Mepolizumab
Reslizumab
IL-13-specific blockers:
Lebrikizumab
Tralokinumab
Dual IL-4 and IL-13 blockers:
Dupilumab
IgE-blockers:
Ligelizumab
Omalizumab
References
Kata Kunci Pencarian: type 2 inflammation
type 2 inflammation
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Type 2 inflammation - Wikipedia
Type 2 inflammation is a pattern of immune response. Its physiological function is to defend the body against helminths , but a dysregulation of the type 2 inflammatory response has been implicated in the pathophysiology of several diseases.
Understanding Type 2 Inflammation | For Healthcare Professionals
Learn more about Type 2 inflammation across patients in multiple disease states.
Type 2 Inflammation: Conditions, Symptoms, and More - Healthline
May 8, 2023 · Type 2 inflammation is a specific immune response that happens throughout the body. It fights against parasitic infections, in particular parasitic worms. But in some cases, the...
Type 2 chronic inflammatory diseases: targets, therapies and …
Aug 1, 2023 · Here, we review common targets, current treatments and emerging therapies for the treatment of five major type 2 chronic inflammatory diseases — atopic dermatitis, chronic prurigo,...
Type 2 Inflammation | AAFA.org
Type 2 inflammation plays a role in certain medical conditions. It causes allergic (or atopic) diseases, such as atopic dermatitis (a form of eczema) and asthma.
Chronic Inflammation: Associated Conditions and Symptoms
Dec 4, 2023 · Type 2 diabetes: Chronic inflammation contributes to insulin resistance—a hallmark of type 2 diabetes. Persistent inflammation disrupts normal insulin signaling, resulting in elevated blood sugar levels and the development of diabetes.
Type 2 immunity‐driven diseases: Towards a multidisciplinary …
Specific phenotypes of cutaneous and respiratory diseases share a common endotype: type 2 inflammation. Better understanding of type 2 inflammation leads to common innovative therapeutic strategies among such diseases. Uncertainties remain and critical unmet needs should be resolved to improve healthcare of such diseases. 1. INTRODUCTION.
Type 2 Inflammatory Disease - American College of Allergy …
Type 2 inflammatory disease occurs when your immune system overreacts, sometimes to something harmless like tree or grass pollen or certain foods. This overreaction leads to ongoing inflammation in your body and is tied to several allergic conditions.
What is Type 2 Inflammation? - Allergy & Asthma Network
Type 2 inflammation is an overactive immune response that causes excess inflammation in the body. It plays a significant role in severe and sometimes chronic diseases. These include respiratory, skin and atopic diseases, including asthma, allergies and eczema (atopic dermatitis).
Understanding Type 2 Inflammation - Allergy & Asthma Network
Type 2 inflammation is a unique immune reaction that leads to extra swelling in the body. It happens when certain immune cells and chemicals, including Th2 cells, cytokines (IL-4, IL-5, IL-13), immunoglobulin E (IgE) antibodies and eosinophils, work together to create Type 2 …