- Boeing XPB
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- Xeroderma pigmentosum
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XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.
Structure
The 3D-structure of the archaeal homolog of XPB has been solved by X-ray crystallography by Dr. John Tainer and his group at The Scripps Research Institute.
Function
XPB plays a significant role in normal basal transcription, transcription coupled repair (TCR), and nucleotide excision repair (NER). Purified XPB has been shown to unwind DNA with 3’-5’ polarity.
The function of the XPB(ERCC3) protein in NER is to assist in unwinding the DNA double helix after damage is initially recognized. NER is a multi-step pathway that removes a wide range of different DNA damages that distort normal base pairing. Such damages include bulky chemical adducts, UV-induced pyrimidine dimers, and several forms of oxidative damage. Mutations in the XPB(ERCC3) gene can lead, in humans, to xeroderma pigmentosum (XP) or XP combined with Cockayne syndrome (XPCS). Mutant XPB cells from individuals with the XPCS phenotype are sensitive to UV irradiation and acute oxidative stress.
XPB helicase is also a component of the p53-mediated programmed cell death (apoptosis) pathway.
Disorders
Mutations in XPB and other related complementation groups, XPA-XPG, leads to a number of genetic disorders such as Xeroderma pigmentosum, Cockayne's syndrome, and trichothiodystrophy.
Interactions
XPB has been shown to interact with:
Small molecule inhibitors
Potent, bioactive natural products like triptolide that inhibit mammalian transcription via inhibition of the XPB subunit of the general transcription factor TFIIH has been recently reported as a glucose conjugate for targeting hypoxic cancer cells with increased glucose transporter expression.
See also
XP
References
Further reading
External links
GeneReviews/NIH/NCBI/UW entry on Xeroderma Pigmentosum
XPBC-ERCC-3+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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Apr 7, 2018 · XPB Images. Recent Events. 13 - 16 February 2025; WRC Rally Sweden; 22 - 26 January 2025; WRC Rally Monte Carlo; 21 - 22 January 2025; Lewis Hamilton - Ferrari; 10 December 2024; F1 Testing Abu Dhabi; 5 - 8 December 2024; Abu Dhabi GP; 6 - 8 December 2024; FIA Formula 2, Round 14, Yas Island;
Kevin Magnussen (DEN) Haas VF-24. 28.07.2024. Formula 1 …
Jul 28, 2024 · Kevin Magnussen (DEN) Haas VF-24. 28.07.2024. Formula 1 World Championship, Rd 14, Belgian Grand Prix, Spa Francorchamps, Belgium, Race Day. - www.xpbimages.com, …
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09.10.2011 Suzuka, Japan, Sebastian Vettel (GER), Red Bull Racing new world champion celebrates with the team - Formula 1 World Championship, Rd 15, Japanese Grand Prix, Sunday Podium - www.xpb.cc, EMail: info@xpb.cc - copy of publication required for printed pictures.
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Fernando Alonso (ESP) Aston Martin F1 Team AMR24. 28.07.2024. Formula 1 World Championship, Rd 14, Belgian Grand Prix, Spa Francorchamps, Belgium, Race Day. - www.xpbimages.com, EMail: requests@xpbimages.com © Copyright: Rew / XPB Images Headline Motor Racing - Formula One World Championship - Belgian Grand Prix - Race Day - …
Logan Sargeant (USA) Williams Racing FW46 makes a pit stop.
Logan Sargeant (USA) Williams Racing FW46 makes a pit stop. 28.07.2024. Formula 1 World Championship, Rd 14, Belgian Grand Prix, Spa Francorchamps, Belgium, Race Day. - www.xpbimages.com, EMail: requests@xpbimages.com © Copyright: Charniaux / …
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33, Elfyn Evans, Scott Martin, Toyota GR Yaris Rally1 HYBRID. 27-31.03.2024. FIA World Rally Championship, Rd 3, Safari Rally Kenya, Naivasha, Kenya
Lewis Hamilton (GBR) Mercedes AMG F1 W15. 22.09.2024.
Sep 22, 2024 · Lewis Hamilton (GBR) Mercedes AMG F1 W15. 22.09.2024. Formula 1 World Championship, Rd 18, Singapore Grand Prix, Marina Bay Street Circuit, Singapore, Race Day. - www.xpbimages.com, EMail: requests@xpbimages.com © Copyright: Rew / XPB Images Headline Motor Racing - Formula One World Championship - Singapore Grand Prix - Race …
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11-13.11.2005 Australia, 02, CITROEN - TOTAL, DUVAL François (BEL), PREVOT Stéphane (BEL), Citroen Xsara WRC - WORLD RALLY CHAMPIONSHIP, Rd.16, Rally Australia - WWW.XPB.CC, EMAIL: INFO@XPB.CC - COPY OF PUBLICATION REQUIRED FOR …
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XPB Images Ltd. is an independant sports agency delivering digital pictures from motorsport events to newspapers, magazines, internetsites, TV stations, teams and sponsors. Access to our internetsite is free and all visitors can view small thumbnails of all pictures in our archive.
Race winner Lando Norris (GBR) McLaren MCL38 takes the …
Sep 22, 2024 · Race winner Lando Norris (GBR) McLaren MCL38 takes the chequered flag at the end of the race. 22.09.2024. Formula 1 World Championship, Rd 18, Singapore Grand Prix, Marina Bay Street Circuit, Singapore, Race Day. - www.xpbimages.com, EMail: requests@xpbimages.com © Copyright: Bearne / XPB Images Headline