- Source: 2alpha-hydroxytaxane 2-O-benzoyltransferase
In enzymology, a 2alpha-hydroxytaxane 2-O-benzoyltransferase (EC 2.3.1.166) is an enzyme that catalyzes the chemical reaction
benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III
⇌
{\displaystyle \rightleftharpoons }
CoA + 10-deacetylbaccatin III
Thus, the two substrates of this enzyme are benzoyl-CoA and 10-deacetyl-2-debenzoylbaccatin III, whereas its two products are CoA and 10-deacetylbaccatin III.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase. This enzyme is also called benzoyl-CoA:taxane 2alpha-O-benzoyltransferase. This enzyme participates in diterpenoid biosynthesis.
References
Walker K, Croteau R (2000). "Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2alpha-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coli". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13591–6. Bibcode:2000PNAS...9713591W. doi:10.1073/pnas.250491997. PMC 17620. PMID 11095755.
