• Source: 6-MeO-DMT

6-MeO-DMT, or 6-methoxy-N,N-dimethyltryptamine, also known as 6-OMe-DMT, is a serotonergic drug of the tryptamine family. It is the 6-methoxy derivative of the serotonergic psychedelic N,N-dimethyltryptamine (DMT) and is a positional isomer of the serotonergic psychedelic 5-MeO-DMT.
Similarly to analogues like DMT and 5-MeO-DMT, 6-MeO-DMT acts as a serotonin 5-HT2A receptor agonist. However, in contrast to these agents, but similarly to certain other serotonin 5-HT2A receptor agonists like 6-fluoro-DET, 2-bromo-LSD, lisuride, 25N-N1-Nap, and tabernanthalog, 6-MeO-DMT does not produce the head-twitch response (HTR) or other psychedelic-like effects in animals and hence appears to be non-hallucinogenic. This is thought to be due to biased agonism of the serotonin 5-HT2A receptor; more specifically, weak activation of the Gq pathway with an efficacy for this pathway of less than 70%. However, the non-hallucinogenic nature of 6-MeO-DMT has yet to be confirmed in humans.
6-MeO-DMT was first described in the scientific literature by 1968. It was specifically assessed in a structure–activity relationship (SAR) animal study of serotonergic tryptamines. The drug's lack of hallucinogen-like effects in animals, as determined by the HTR, was first described by at least 2020.




See also


5-MeO-isoDMT
6-Fluoro-AMT
6-Fluoro-DMT
6-MeO-isoDMT
AAZ-A-154
ITI-1549




References






External links


6-MeO-DMT - isomer design

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