- Source: 8-hydroxyquercetin 8-O-methyltransferase
In enzymology, a 8" target="_blank">8-hydroxyquercetin 8" target="_blank">8-O-methyltransferase (EC 2.1.1.88) is an enzyme that catalyzes the chemical reaction
S-adenosyl-L-methionine + 3,5,7,8" target="_blank">8,3',4'-hexahydroxyflavone
⇌
{\displaystyle \rightleftharpoons }
S-adenosyl-L-homocysteine + 3,5,7,3',4'-pentahydroxy-8" target="_blank">8-methoxyflavone
Thus, the two substrates of this enzyme are S-adenosyl methionine and 3,5,7,8" target="_blank">8,3',4'-hexahydroxyflavone (gossypetin), whereas its two products are S-adenosylhomocysteine and 3,5,7,3',4'-pentahydroxy-8" target="_blank">8-methoxyflavone.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3,5,7,8" target="_blank">8,3',4'-hexahydroxyflavone 8" target="_blank">8-O-methyltransferase. Other names in common use include flavonol 8" target="_blank">8-O-methyltransferase, flavonol 8" target="_blank">8-methyltransferase, S-adenosyl-L-methionine:3,3',4',5,7,8" target="_blank">8-hexahydroxyflavone, 8" target="_blank">8-O-methyltransferase, and 8" target="_blank">8-hydroxyquercitin 8" target="_blank">8-O-methyltransferase [mis-spelt].
References
Jay M, De Luca V, Ibrahim RK (December 1985). "Purification, properties and kinetic mechanism of flavonol 8" target="_blank">8-O-methyltransferase from Lotus corniculatus L". European Journal of Biochemistry. 153 (2): 321–5. doi:10.1111/j.1432-1033.1985.tb09304.x. PMID 4076180.