• Source: Acylsulfonamide

Acylsulfonamide is a functional group in organic chemistry that is sometimes used in medicinal chemistry. It consists of a sulfonamide group (SO2NH) linked to an acyl group (RCO), forming the structure R1-CO-NH-SO2-R2. This moiety is found in several biologically active molecules and marketed drugs, serving as an useful pharmacophore. Acylsulfonamides are of particular interest due to their ability to act as bioisosteres of carboxylic acids, offering similar hydrogen bonding capabilities and comparable pKa values (typically between 3.5-4.5). They are incorporated in various drugs candidates targeting conditions such as bacterial infections, pain, and cancer.




Examples


The following are approved drugs that contain the acylsulfonamide functional group:

Several investigational new drugs contain also the acylsulfonamide functional group. Examples include:




References

Kata Kunci Pencarian:

• Acylsulfonamide
• Venetoclax
• Zafirlukast
• Paritaprevir
• Navitoclax
• Parecoxib
• Gregory L. Verdine
• Selexipag
• Sulfacetamide
• Simeprevir